… This Review provides an overview on the spike (S) protein of severe acute respiratory
syndrome-coronavirus (SARS-CoV) as a target for the development of vaccines and therapeutics …

… spike (S) protein for entry to the host cell, it is one of the most preferred targets for making
vaccines or therapeutics … In this review, we have summarised the characteristics of the S protein…

… of the S protein, summarize the current published vaccine and therapeutic research against
MERS-CoV based on the S protein, and highlight the suitability of the S protein as a target …

… All these antibody-based therapeutics and vaccines suffer from one major risk: mutational
escape of the Spike protein. Changes in Spike protein might also increase transmissibility, …

… Taken together, our findings indicate that the adjuvanted, recombinant, full-length spike
protein nanoparticle vaccine NVX-CoV2373 is a promising candidate that warrants testing in …

… vaccines against SARS-CoV-2. Here, we aimed to review frontier therapeutics and vaccination
… In addition, the spike protein located on the viral membrane has an essential influence on …

… of SARS-CoV-2 S protein in viral infection, as well as the development of therapies and
vaccines. The efficacy and safety of these therapeutic compounds and vaccines are still …

… Almost all vaccine candidates against SARS-CoV-2 are based on the spike protein, … /BioNTech
and Moderna vaccines that use mRNA encoding a modified spike protein stabilized in its …

… Antibody-dependent enhancement (ADE) has been a key issue in CoV vaccines and
therapeutic antibodies, in which antibodies with no, or low-titer, neutralizing activity enhance virus …

… vaccine development are essential. Previous experience from SARS- and MERS-coronavirus
vaccine … and biology, examples of therapeutic and vaccine strategies taken and potential …