SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

T Patra, K Meyer, L Geerling, TS Isbell, DF Hoft… - PLoS …, 2020 - journals.plos.org
… -2 infected and viral spike protein expressing epithelial cells did … Introduction of culture
supernatant from SARS-CoV-2 spikespike protein in epithelial cells promotes IL-6 trans-signaling

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2

J Ettich, J Werner, HT Weitz, E Mueller… - Journal of …, 2022 - Am Soc Microbiol
… viral spike protein to host ACE2, cleavage of the spike protein… on the cleavage of the
spike protein by TMPRSS2 at the … , the spike protein in large IL-6R (target cell)–antibody–spike

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

M Thépaut, J Luczkowiak, C Vivès, N Labiod… - PLoS …, 2021 - journals.plos.org
… -2 Spike Protein In order to accurately analyze the interaction properties of the spike protein
from SARS-CoV-2 with CLRs, we expressed and purified recombinant spike protein using …

SARS-CoV-2 spike protein elicits cell signaling in human host cells: implications for possible consequences of COVID-19 vaccines

YJ Suzuki, SG Gychka - Vaccines, 2021 - mdpi.com
… Vaccines that introduce the spike protein into our body to elicit virus-neutralizing antibodies
… the spike protein to elicit cell signaling. Thus, it is important to be aware that the spike protein

Upregulation of the chemokine (CC motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway

IY Chen, SC Chang, HY Wu, TC Yu, WC Wei… - Journal of …, 2010 - Am Soc Microbiol
spike protein. These results indicate that SARS-CoV spike protein triggers ACE2 signaling
and … Four major structural proteins including spike (S), membrane (M), envelope (E), and …

… after vaccination against SARS-CoV-2 may be derived from a combined effect of SARS-CoV-2 spike protein and adenovirus vector-triggered signaling pathways

R Kircheis - International journal of molecular sciences, 2021 - mdpi.com
… the spike proteinspike protein of SARS-CoV-2, and Ad26.COV2.S (Johnson &
Johnson/Janssen), a recombinant human adenovirus type 26 vector encoding SARS-CoV-2 spike

SARS-CoV-2 spike protein interacts with and activates TLR41

Y Zhao, M Kuang, J Li, L Zhu, Z Jia, X Guo, Y Hu… - Cell research, 2021 - nature.com
… data that TLR4 signaling was activated by SARS-CoV-2, we hypothesized that spike protein
could … A recent study has reported that trimeric SARS-CoV-2 spike proteins are high quality …

SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells

K Meyer, T Patra, Vijayamahantesh, R Ray - Journal of virology, 2021 - Am Soc Microbiol
… coronavirus 2 (SARS-CoV-2) spike protein promotes an inflammatory cytokine interleukin
6 (IL-6)/IL-6R-induced trans signaling response and alarmin secretion. Virus-infected or …

[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… Here, we aimed to explore the regulatory role of SARS-CoV-2 spike protein in infected cells
and attempted to elucidate the molecular mechanism of SARS-CoV-2-induced inflammation. …

Recombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus

Ł Suprewicz, KA Tran, E Piktel, K Fiedoruk… - Journal of …, 2022 - Springer
… effect of spike proteins on the downregulation of TJs protein … for genes involved in VEGF
signaling and activation of blood–… of signaling pathways triggered by the SARS-CoV-2 Spike