… for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins

AA Elmaaty, KM Darwish, M Khattab… - Journal of …, 2022 - Taylor & Francis
… (glycyrrhizin, lycorine, salvianolic acid B, dihydrotanshinone, tanshinone I, … proteins of
SARS-CoV-2 (3CLpro, and S-protein). Molecular docking study highlighted that Salvianolic acid-B (…

Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

C Yang, X Pan, X Xu, C Cheng, Y Huang, L Li… - Signal transduction and …, 2020 - nature.com
… We herein report that the hydrophilic compound Salvianolic acid C (Sal-C) from Danshen, a
… -helix bundle (6-HB) core of spike (S) protein. The spike protein of SARS-CoV-2 plays a key …

Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2

S Hu, J Wang, Y Zhang, H Bai, C Wang… - Journal of medical …, 2021 - Wiley Online Library
… of 2019-nCoV SpikeSalvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus
into ACE2 h cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein

Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion

C Yang, C Cheng, J Wang, K Chen, J Zhan… - … Fang yi ke da xue xue …, 2021 - europepmc.org
Objective The investigate the inhibitory effects of the traditional Chinese medicine (TCM)
monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza Polyphenolate …

Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro …

D Elebeedy, WF Elkhatib, A Kandeil, A Ghanem… - RSC …, 2021 - pubs.rsc.org
… as spike protein inhibitors that halting the fusion of the spike (S) … As it can be seen from the
ligands RMSD, salvianolic acidSalvianolic acid reaches equilibrium in the case of S protein, …

Exploring the binding effects of natural products and antihypertensive drugs on SARS-CoV-2: an in silico investigation of main protease and spike protein

K Moschovou, M Antoniou, E Chontzopoulou… - International Journal of …, 2023 - mdpi.com
… -2 Spike protein and ACE2. At the first binding site on the Spike protein (chain E), salvianolic
acid b … that the binding between salvianolic acid b and the SARS-CoV-2 S protein at the first …

Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19

SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - Cells, 2022 - mdpi.com
… [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by
blocking spike protein-mediated membrane fusion]. Nan Fang Yi Ke Da Xue Xue Bao 2021, …

… , and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein

H Li, C Cheng, S Shi, Y Wu, Y Gao, Z Liu, M Liu… - European Journal of …, 2022 - Elsevier
… Moreover, our group has previously reported that the natural polyphenol compound salvianolic
acid C (Sal-C) from Danshen, is able to potently suppress SARS-CoV-2 infection in vitro …

[HTML][HTML] Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection

Y Yi, J Li, X Lai, M Zhang, Y Kuang, YO Bao… - Journal of advanced …, 2022 - Elsevier
… A3 mainly targets the nsp7 protein, and GA binds to the spike protein RBD of SARS-CoV-2. …
acid potently inhibit SARS-CoV-2 infection, targeting the nsp7 protein and the spike protein

Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19

B Zhang, F Qi - BioScience Trends, 2023 - jstage.jst.go.jp
protein; the three compounds with the highest affinity were anhydrosafflor yellow B, salvianolic
acid … Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to …