Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

W Wang, S Li, X Xu, C Yang, X Niu, S Yin… - Acta Pharmacologica …, 2022 - nature.com
… mouse model of ALI induced by Spike protein. As to the instable … Previous studies showed
that Salvianolic acid B and sodium … Our previous results also indicated that Salvianolic acid C …

[PDF][PDF] Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19. Cells 2022, 11, 1311

SJL Petitjean, M Lecocq, C Lelong, R Denis, S Defrère… - 2022 - academia.edu
… B (SAB), and salvianolic acid C (SAC)) can inhibit the entry … ) of the SARS-CoV-2 spike protein
and the specific host cellular … Three salvianolic acids inhibit 2019-nCoV spike pseudovirus …

Nanopore analysis of salvianolic acids in herbal medicines

P Fan, S Zhang, Y Wang, T Li, H Zhang… - Nature …, 2024 - nature.com
salvianolic acids, including caffeic acid, protocatechuic acid, protocatechualdehyde, salvianic
acid A, rosmarinic acid, lithospermic acid, salvianolic acid A … to assist protein purification by …

In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors

MAA Ibrahim, AHM Abdelrahman, TA Hussien… - Computers in Biology …, 2020 - Elsevier
… This study establishes salvianolic acid A as an in silico natural … and are named for distinctive
protein spikes covering the virus' outer … Salvianolic acid A and curcumin protein targets were …

Bioinformatic screening of compounds from Iranian lamiaceae family members against SARS-CoV-2 spike protein

A Alibakhshi, S Gharibi… - Letters in Drug …, 2023 - ingentaconnect.com
spike protein with its receptor (ACE2) and in interaction with the ligands in this study is
determined. It is clear that in the complexes of spike … of the binding site of spike protein are more …

Chemical Composition of Rosemary (Rosmarinus officinalis L.) Extract and Its Inhibitory Effects on SARS-CoV-2 Spike Protein–ACE2 Interaction and ACE2 Activity …

Y Yao, U Choe, Y Li, Z Liu, M Zeng… - Journal of Agricultural …, 2023 - ACS Publications
… in rosemary such as rosmarinic acid, salvianolic acid B, and carnosol. (4) In the case of
SARS-CoV-2, similar compounds such as rosmarinic acid and salvianolic acid B that showed …

Identification of main protease of coronavirus SARS-CoV-2 (Mpro) Inhibitors from Melissa officinalis

OO Elekofehinti, O Iwaloye… - Current drug …, 2021 - ingentaconnect.com
… within a capsid comprised of matrix protein [5]. It belongs to a … Covid-19 utilizes its spike
protein to bind human angiotensin-… In the present study, salvianolic acid A seems to have better …

Screening S protein–ACE2 blockers from natural products: strategies and advances in the discovery of potential inhibitors of COVID-19

H Liu, X Liu, X Yuan, C Xu, F Wang, J Lin, R Xu… - European Journal of …, 2021 - Elsevier
… Delta strain has multiple mutations in the spike protein that give it both greater ACE2 receptor
binding ability and immune escape ability. Delta strain grows more rapidly in the lung and …

Salvianolic acid B: a review of pharmacological effects, safety, combination therapy, new dosage forms, and novel drug delivery routes

G He, G Chen, W Liu, D Ye, X Liu, X Liang, J Song - Pharmaceutics, 2023 - mdpi.com
… , salvianolic acid B downregulates the protein expression of NLRP3 and its associated proteins
ASC … SARS-CoV-2 spike protein-mediated virus–cell membrane fusion [197] (Table 12). …

Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

Y Xiang, G Zhai, Y Li, M Wang, X Chen, R Wang… - International journal of …, 2023 - Elsevier
… Targeting the interaction between the spike protein receptor binding domain (S-RBD) of …
protein-protein interaction. Here, we used NanoBiT technology to identify three Ginkgolic acids