Salvianolic Acid B inhibits high‐fat diet‐induced inflammation by activating the Nrf2 pathway

B Wang, J Sun, Y Shi, G Le - Journal of food science, 2017 - Wiley Online Library
… HFD produced a noticeable spike in body weight in the HF mice in comparison to the …
NF-κBp65 proteins in mice that were fed a HFD We determined the amount of Nrf2 protein in the …

Establishment of an at-line nanofractionation-based screening platform by coupling HPLC-MS/MS with high-throughput fluorescence polarization bioassay for natural …

J Yuan, J Wang, Z Chen, Y Chang, L Chen… - … of Chromatography A, 2024 - Elsevier
proteins of SARS-CoV-2 [2]. Studies have shown that the S1 subunit and S2 subunits
belonging to spike (S) protein … containing salvianolic acid A, salvianolic acid B, chlorogenic acid

[HTML][HTML] Computational screening approaches for investigating potential activity of phytoligands against SARS-CoV-2

A Balkrishna, P Thakur, S Singh, S Narsingh, N Singh… - 2020 - europepmc.org
… -2 spike glycoprotein (viral envelope protein responsible for … salvianolic acid presumably
indicates the probable mechanism of action of these phytomolecules as viral protease, spike

Impact of traditional plants and their secondary metabolites in the discovery of COVID-19 treatment

S Bibi, A Sarfraz, G Mustafa, Z Ahmad… - Current …, 2021 - ingentaconnect.com
… Emodin extracted from it was tested for interaction study of SARS-CoV (S) protein to
angiotensin-converting enzyme 2. It significantly blocked SARS-CoV spike protein and angiotensin-…

A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

Y Cai, W Xu, J Tang, N Cao, Q Lan, L Lu, S Jiang - Cell & Bioscience, 2021 - Springer
spike (S) protein [3]. Such binding triggers conformation changes in the S2 subunit of S protein
and consists of 121 amino acids [10] able to interact with glycans displayed on SARS-CoV…

Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti …

R Wang, X Chen, H Li, X Chen, D Sun, D Yu… - International Journal of …, 2024 - Elsevier
Salvianolic acid A, salvianolic acid B, and salvianolic acid C as the main water-soluble
components of Salvia miltiorrhiza could inhibit the entry of SARS-CoV-2 spike … and spike protein

In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus

D Elebeedy, I Badawy, AA Elmaaty, MM Saleh… - Computers in biology …, 2022 - Elsevier
protein of influenza A virus as follows: salvianolic acid (6) ˃ rosmarinic acid (3) ˃ glycyrrhetinic
acid (4) ˃ carnosic acidprotein of influenza A virus was: salvianolic acid (6) ˃ rosmarinic …

Natural products and phytochemicals as potential anti‐SARS‐CoV‐2 drugs

M Merarchi, N Dudha, BC Das… - Phytotherapy Research, 2021 - Wiley Online Library
Spike protein (S) to the ACE receptor present on the lung epithelial cell surface followed by
cleavage of S protein … included aster pentapeptide A, ligustrazine, salvianolic acid B, etc., and …

Inhibitory effects of salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

LQ Sun, B Xue, XJ Li, X Wang, L Qu, TT Zhang, J Zhao… - Life sciences, 2012 - Elsevier
AIMS: To investigate protective effects of Salvianolic acid B (Sal B) on the intermittent high
glucose (IHG)-induced oxidative stress, mitochondrial pathway activation and Schwann cell (…

[HTML][HTML] Recent progress of surface plasmon resonance in the development of coronavirus disease-2019 drug candidates

Q Wang, Z Liu - European Journal of Medicinal Chemistry Reports, 2021 - Elsevier
Spike protein is the most important surface membrane protein of SARS-CoV-2, which
contains two subunits S1 and S2. S1 mainly contains the N-terminal domain (NTD), the receptor …