Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies

S Mousavi, S Zare, M Mirzaei… - Canadian Journal of …, 2022 - Wiley Online Library
… compounds Nonstructural protein 9 (Nsp9) replicase and spike proteins Conivaptan …
potency of salvianolic acid A and curcumin as main protease inhibitors Salvianolic acid A as …

A robust high-throughput fluorescent polarization assay for the evaluation and screening of SARS-CoV-2 fusion inhibitors

X Yin, L Chen, S Yuan, L Liu, Z Gao - Bioorganic Chemistry, 2021 - Elsevier
… The IC 50 of known inhibitors, HR2P, EK1, and Salvianolic acid C (Sal-C) were measured to
… true binding strength between Sal-C and spike protein in its prefusion state. In a competitive …

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

YF Huang, C Bai, F He, Y Xie, H Zhou - Pharmacological research, 2020 - Elsevier
… AEC2 and 3CL protein could be the direct targets for inhibiting severe acute respiratory …
-19 by targeting on AEC2 and 3CL protein and inhibiting inflammatory mediators, regulating …

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

VA Tirado-Kulieva, E Hernández-Martínez… - Heliyon, 2022 - cell.com
… ) and their target proteins, it is postulated that natural medicine has a high potential to address
current SARS-CoV-2. Since the spread of the disease in China, based on the experiences …

Recent perspectives on COVID-19 and computer-aided virtual screening of natural compounds for the development of therapeutic agents towards SARS-CoV-2

D Gopal, S Skariyachan - In Silico Modeling of Drugs Against …, 2021 - Springer
… , which include are structures of spike glycoprotein in the post-… The open and closed
conformations of the spike protein are … aster pentapeptide A, and salvianolic acid B. Similarly, …

Computational screening of plant-derived natural products against SARS-CoV-2 variants

WA Ansari, MA Khan, F Rizvi, K Ali, MK Hussain… - Future …, 2022 - mdpi.com
proteins such as spike glycoprotein (S), an envelope protein (E), nucleocapsid protein (N)
and matrix protein (… , where they interact with spike proteins (S-protein), a trimeric protein, with …

[引用][C] Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo …

HA El Gizawy, SA Boshra, A Mostafa, SH Mahmoud… - Molecules, 2021 - MDPI

Effects of salvianolic acid B and tanshinone IIA on the pharmacokinetics of losartan in rats by regulating the activities and expression of CYP3A4 and CYP2C9

R Wang, H Zhang, Y Wang, X Yu, Y Yuan - Journal of Ethnopharmacology, 2016 - Elsevier
… and salvianolic acid B and the tanshinones) up-regulated CYP1A2 protein expression and
… Matrix effect was assayed to compare (a) the peak areas of blank plasma extracts spikes

Molecular insight into the therapeutic promise of xuebijing injection against coronavirus disease 2019

D Zhang, JT Lv, B Zhang, RN Sa, BB Ma… - World Journal of …, 2020 - journals.lww.com
… and site between dominant components and critical receptor proteins (3CLpro, angiotensin-…
Moreover, the compounds from the herbal plant, Danshen, including Salvianolic acid B and …

Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019

X Yan, HUA Ying-Rong, J Shang, GE Wei-Hong… - Chinese journal of …, 2020 - Elsevier
… 19 3 CL protease(3CLpro), spike protein (S protein), and angiotensin-converting enzyme
II (… ), salvianolic acid B (SAB), and rutin could combine with COVID-19 crucial proteins, and …
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