[HTML][HTML] Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2

S Ge, J Lu, Y Hou, Y Lv, C Wang, H He - Virology, 2021 - Elsevier
… By binding to ACE2, azelastine interferes with the interaction between spike protein and
ACE2 and reduces the infection of SARS-CoV-2, which is a promising virus entry inhibitor. …

Multitarget in silico studies of Ocimum menthiifolium, family Lamiaceae against SARS-CoV-2 supported by molecular dynamics simulation

A Albohy, EM Zahran, UR Abdelmohsen… - Journal of …, 2022 - Taylor & Francis
… particle is maintained via four proteins: The S (spike), E (envelop), M (membrane) and N (nucleocapsid)
proteins (Han & Král, Citation2020), where the S protein mediates the entry of …

Plant Immunoenhancers: Promising Ethnopharmacological Candidates for Anti-SARS-CoV-2 Activity

SH Ghoran, SA Ayatollahi - Jen-Tsung Chen Editor - Springer
… Using a molecular docking study, salvianolic acid A (29)(Fig. 3.5) obtained from S. officinalis
… , it is revealed that curcumin interacted with spike protein or ACE2 protein in the COVID-19-…

Chemical system biology approach to identify multi-targeting FDA inhibitors for treating COVID-19 and associated health complications

B Naik, VSK Mattaparthi, N Gupta, R Ojha… - Journal of …, 2022 - Taylor & Francis
… against the target proteins including spike protein, spike protein complex with ACE2, PL …
; and one cardioprotective compound such as Salvianolic Acid B, that could effectively interact …

[HTML][HTML] Synthesis and in vitro study of antiviral activity of glycyrrhizin nicotinate derivatives against HIV-1 pseudoviruses and SARS-CoV-2 viruses

VV Fomenko, NB Rudometova, OI Yarovaya… - Molecules, 2022 - mdpi.com
… In this work, derivatives of Glyc obtained by acylation with nicotinic acid were investigated.
The resulting preparation, Glycyvir, is a multi-component mixture containing mainly mono-, di-, …

Two resveratrol oligomers inhibit cathepsin L activity to suppress SARS-CoV-2 entry

C Wang, X Ye, C Ding, M Zhou, W Li… - Journal of Agricultural …, 2023 - ACS Publications
… The spike (S) protein on the surface of SARS-CoV-2 is … We detected the levels of S protein
in the virion of S-… expressed the S protein of SARS-CoV-2 and hACE2 protein, respectively (…

[HTML][HTML] Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome

Y Li, Y Wu, S Li, Y Li, X Zhang, Z Shou, S Gu… - Biomedicine & …, 2022 - Elsevier
… However, the emergence of SARS-CoV-2 variants with spike (S) protein mutations that …
Our previous study found that salvianolic acid C inhibits SARS-CoV-2-mediated membrane …

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

R Du, L Cooper, Z Chen, H Lee, L Rong, Q Cui - Antiviral research, 2021 - Elsevier
The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date,
there are limited therapeutic options available to fight this disease. Here we examined the …

[HTML][HTML] Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities?

A Hasan, P Biswas, TA Bondhon, K Jannat, TK Paul… - Molecules, 2022 - mdpi.com
… because of the high number of mutations in the spike protein region [12]. A number of …
inhibit the virus through binding with the 3C-like protease or spike protein of CoV-2 [18,19]. …

Molecular docking study of seventy-six phytomolecules from sixteen aromatics medicinal plants as promising inhibitors of five non-structural proteins of SARS-CoV-2

T RANDRIAMAMISOLONIRINA… - GSC Biological and …, 2022 - gsconlinepress.com
… These proteins are selected for their involvement in virus … Table 1 The non-structural proteins
used in this study … and the prediction of the active site residues of these targeted proteins. …