Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

MI Barton, SA MacGowan, MA Kutuzov, O Dushek… - Elife, 2021 - elifesciences.org
common and therefore important variants of RBD and ACE2. Henceforth, we will refer to the
common ACE2 allele and RBD of … We chose mutations of RBD within the ACE2 binding site …

Comparative structural analyses of selected spike protein-RBD mutations in SARS-CoV-2 lineages

U Roy - Immunologic Research, 2022 - Springer
mutations. Two supplementary simulations were performed, with wt S1 and the delta variant
with selected S1 mutations… The mutations considered in this report are found in the RBD and …

[HTML][HTML] Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics development

K Guruprasad - Current research in structural biology, 2022 - Elsevier
… The other amino acid substitutions observed at the most common mutated position 614 in
human SARS-CoV-2 spike … The L452R mutation, which is the predominant spike protein RBD

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
… N439K is one of the most common RBD mutations occurring independently worldwide.
However, its prevalence in India is lower in frequency as compared globally. This …

Human SARS CoV‐2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
… The locations of mutations in RBD (S1 B domain) of the spike protein were mapped on to
the three-dimensional crystal structure available in the Protein Data Bank (PDB) 20 (PDB code: …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
… Sites of the RBD shown in red harbor mutations of concern either due to enhanced
antibody evasion or effects on transmission. Figure 2b and Figure 2c show the corresponding …

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

Z Zhang, J Zhang, J Wang - Frontiers in Public Health, 2022 - frontiersin.org
common mutations in RBD. Description of VOCs and VOIs' most common mutations in the
RBD … Here, only changes of binding affinity between S and hACE2 caused by RBD mutations

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SMC Gobeil, K Janowska, S McDowell, K Mansouri… - Science, 2021 - science.org
… All variants showed increased binding to ACE2, which was mediated by higher
propensity for RBD-up states, and affinity-enhancing mutations in the RBD. We observed …

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
… -labeled RBD protein (100 nM). Concentrations used for unlabeled RBD and RBD mutants
… determine the role of the receptor mutations, we first compared the ability of all of the RBD

Mutations and evolution of the SARS-CoV-2 spike protein

N Magazine, T Zhang, Y Wu, MC McGee, G Veggiani… - Viruses, 2022 - mdpi.com
… by which the common mutations on the spike protein that … these mutations within the context
of the SARS-CoV-2 spike … of mutations within the RBD (magenta) of SARS-CoV-2 spike. …