[HTML][HTML] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

P Han, L Li, S Liu, Q Wang, D Zhang, Z Xu, P Han, X Li… - Cell, 2022 - cell.com
… We also include the RBD of GD/1/2019, a pangolin-origin coronavirus closely related to
SARS-CoV-2. The mapping demonstrated that omicron RBD carries an unusually high number …

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

WN Voss, YJ Hou, NV Johnson, G Delidakis, JE Kim… - Science, 2021 - science.org
coronavirus 2 (SARS-CoV-2) spike ectodomain (S-ECD) folds into a multidomain architecture
(1, 2) and includes the receptor binding domain (RBD), … Humoral immunity to the spike (S) …

The spike of concern—the novel variants of SARS-CoV-2

A Winger, T Caspari - Viruses, 2021 - mdpi.com
… The N-terminal S1-domain of spike contains the receptor binding domain (RBD, 319–541aa)
where 17 amino acids make direct contact with hAce2 at the plasma membrane of the …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… hACE2 binding affinity between SARS-CoV-2 RBD and spike, combined with … RBD in
SARS-CoV-2 spike, suggests that the hidden RBD contributes to the immune evasion of SARS-CoV

Differential interactions between human ACE2 and spike RBD of SARS-CoV-2 variants of concern

S Kim, Y Liu, Z Lei, J Dicker, Y Cao… - Journal of chemical …, 2021 - ACS Publications
… the enhanced interactions between RBD and ACE2. However, … residues across viral variants
in the RBD–ACE2 interface. … between human ACE2 and RBD of SARS-CoV-2 of all variants …

[HTML][HTML] Recent advances in SARS-CoV-2 spike protein and RBD mutations comparison between new variants alpha (B. 1.1. 7, United Kingdom), Beta (B. 1.351 …

PRS Sanches, I Charlie-Silva, HLB Braz, C Bittar… - Journal of virus …, 2021 - Elsevier
… in other amino acids from Spike protein (S) could affect virus infection despite his … SARS-CoV-2
is of broad and immediate interest. In the present study, we assess the impact of the RBD

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
… To elucidate the interaction between the RBD of SARS-CoV-2 variants and ACE2, we
performed a cell-surface-binding assay. ACE2 with a mCherry fused at the C-terminus was …

Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants

CHS da Costa, CAB de Freitas, CN Alves… - Scientific Reports, 2022 - nature.com
… of SARS-CoV-2 virus. Mutations on the Spike (S) protein receptor-binding domain (RBD)
are critical for the antibody resistance and infectivity of the SARS-CoV-2 variants. In this study, …

SARS-CoV-2 and SARS-CoV spike-RBD structure and receptor binding comparison and potential implications on neutralizing antibody and vaccine development

C Sun, L Chen, J Yang, C Luo, Y Zhang, J Li, J Yang… - Biorxiv, 2020 - biorxiv.org
… The above studies confirm that both SARS-CoV-2 and SARS-CoV have … spike RBDs between
SARS-CoV-2 and SARS-CoV, it is of significant interest to investigate whether SARS-CoV

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… show that the SARS-CoV-2 RBD–ACE2 and SARS-CoV RBD–ACE2 … of the SARS-CoV-2
and SARS-CoV RBD structures to … SARS-CoV-2 does not cluster within SARS-CoV and SARSr-…