… coronavirus 2 (SARS-CoV-2) spike ectodomain (S-ECD) folds into a multidomain architecture (1, 2) and includes the receptor binding domain (RBD), … Humoral immunity to the spike (S) …
… The N-terminal S1-domain of spike contains the receptor binding domain (RBD, 319–541aa) where 17 amino acids make direct contact with hAce2 at the plasma membrane of the …
J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… hACE2 binding affinity between SARS-CoV-2 RBD and spike, combined with … RBD in SARS-CoV-2 spike, suggests that the hidden RBD contributes to the immune evasion of SARS-CoV…
S Kim, Y Liu, Z Lei, J Dicker, Y Cao… - Journal of chemical …, 2021 - ACS Publications
… the enhanced interactions between RBD and ACE2. However, … residues across viral variants in the RBD–ACE2 interface. … between human ACE2 and RBD of SARS-CoV-2 of all variants …
… in other amino acids from Spike protein (S) could affect virus infection despite his … SARS-CoV-2 is of broad and immediate interest. In the present study, we assess the impact of the RBD …
F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
… To elucidate the interaction between the RBD of SARS-CoV-2 variants and ACE2, we performed a cell-surface-binding assay. ACE2 with a mCherry fused at the C-terminus was …
… of SARS-CoV-2 virus. Mutations on the Spike (S) protein receptor-binding domain (RBD) are critical for the antibody resistance and infectivity of the SARS-CoV-2 variants. In this study, …
C Sun, L Chen, J Yang, C Luo, Y Zhang, J Li, J Yang… - Biorxiv, 2020 - biorxiv.org
… The above studies confirm that both SARS-CoV-2 and SARS-CoV have … spike RBDs between SARS-CoV-2 and SARS-CoV, it is of significant interest to investigate whether SARS-CoV …
J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… show that the SARS-CoV-2 RBD–ACE2 and SARS-CoVRBD–ACE2 … of the SARS-CoV-2 and SARS-CoVRBD structures to … SARS-CoV-2 does not cluster within SARS-CoV and SARSr-…