… -CoV-2 spike protein receptor-binding domain (RBD) is the … occurring RBD mutations
during the early transmission phase … SARS-CoV-2 RBD mutants and the human angiotensin-…

… in silico the structural dynamics of the RBD-spike protein mutation enhancing ACE2-… RBD
region displayed higher affinity to ACE2 due to the improved interfacial stability of the RBD …

… the University of Saskatchewan which is in Phase I/II trials 5 . In … based on recombinant
monomeric spike RBD protein, a … also reported in the Novavax Phase I study where the lower 5 …

… antigen among 14 representative COVID-19 patients during the acute phase since illness
onset. The first sample (green) and follow-up sample (red) are connected by black arrow. The …

… transmission 34 . Whereas the essential evolution and consequent mutation of SARS-CoV-2
takes place remotely from the RBD in the Spike … mutations at different Spike protein domains …

… phase with the extinction of the α helices. The E484K mutation in this variant may show
higher level of stability as some coils and turns are converted to few β sheets near the last phase …

… -binding domain (RBD) at viral surface spike (S) protein to interact with the angiotensin-converting
enzyme 2 (ACE2) receptor expressed on many human cell types. The RBD-ACE2 …

… the N501Y and S477N mutations enhance transmission primarily by enhancing binding, the
… The right panel shows an expanded view of the dissociation phase. The blue lines show the …

… Among 1609 genomes of SARS-CoV-2 strains isolated during the early transmission
phase, 32 non-synonymous RBD mutants were identified and found clustered into nine mutant …

… The baseline interference phase was obtained by … infectibility of natural RBD mutations during
the transmission of the virus (… SARS-CoV-2 RBD and SARS-CoV RBD by using a panel of …