… the open conformation of RBD and thus enhanced the binding capacity of the spike protein
to ACE2 and infectivity of SARS-CoV-2. Mutational analysis revealed that all of the infectivity-…

… and is outside the RBD of the SARS-CoV-2 spike protein. It has been confirmed that the
D614G mutants, which have spread widely, increase virus infectivity by elevating its sensitivity to …

… spike protein receptor-binding domain (RBD) is the critical determinant of viral tropism and
infectivity… mutations in the RBD have altered the receptor binding affinity and infectivity, firstly …

… This change may destabilize the locked conformation to promote receptor binding domain
(RBD) opening and potentially increase virus-receptor binding and membrane fusion activities…

… the virus, with more than 90% of broadly neutralizing antibodies from either infected patients
or vaccinated individuals targeting the spike RBD. Therefore, mutations in the RBD region …

… spike in the circulating viruses. As it is a heavily glycosylated protein, investigation of the
effects of the site-specific glycans on infectivity … by deleting the two glycosylation sites in RBD. …

… Currently, the virus infection in individuals and at the population level is being monitored
by … spike RBD antigens from different CoVs. (E) Binding characterization of the spike RBD …

… D614G S is associated with increased infectivity and viral load in patients with COVID-19. …
and RBD opening, likely leading to increased ACE2 binding and elevated viral infectivity. …

… features an amino acid substitution in the Spike RBD (N501Y mutation). … infectivity of the
B.1.1.7 lineage might be due to changes in the interaction force between the mutant Spike RBD …

… The mutations, especially those that occurred on the spike (S) protein receptor-binding domain
(RBD), are of significant concern due to their potential capacity to increase viral infectivity, …