… Neutralizing antibodies provide efficient blockade for viral infection and are … spike
receptor-binding domain (RBD) as a bait, we generate a panel of humanized single domain …

… -based diagnostic assays, we focused on the RBD domain of the spike protein because this
… target of human antibodies (19). A major concern with using a protein domain instead of a full…

Tools to monitor SARS-CoV-2 transmission and immune responses are needed. We present
a neutralization ELISA to determine the levels of Ab-mediated virus neutralization and a …

… A detailed characterization of antibody responses is needed to determine whether antibody-…
the kinetics and antibody isotype profile to the receptor binding domain (RBD) of the spike (S…

… SARS-CoV-2 Spike protein and determine the proportion of anti-Spike antibodies that
block … ), we present natively folded viral Spike protein receptor-binding domain (RBD)-containing …

… showed that the spike RBD could induce potent and persistent antibody responses in the …
in the immunoaffinity column, the anti-RBD antibodies purified from the positive human serum …

… receptor engagement, is a potential therapeutic target. We describe the development of a
phage-displayed single-domain antibody … cryptic epitope located in the spike trimeric interface. …

The receptor binding domain (RBD) of the spike (S) glycoprotein of severe acute respiratory
syndrome coronavirus (SARS-CoV) is a major target of protective immunity in vivo. Although …

… a neutralizing monoclonal antibody (MAb)… receptor-binding domain (RBD) of the MERS-CoV
spike protein and thereby competitively blocks the binding of the RBD to its cellular receptor…

… 2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores. The receptor-binding
domain (… Our results explain the immunodominance of the receptor-binding motif and will …