Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
… injury, is a prominent finding in status epilepticus. Blood–brain barrier dysfunction is observed
within the first hour of status epilepticus, and in epileptogenic brain regions, may last for …

Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis

JA Gorter, EA van Vliet, E Aronica - Epilepsy & Behavior, 2015 - Elsevier
… focused on dysfunction of the cerebral vasculature and inflammation as important players
in epileptogenic processes, with a specific emphasis on failure of the blood–brain barrier (BBB…

Pathophysiology of status epilepticus

MC Walker - Neuroscience letters, 2018 - Elsevier
… inflammation, break down of the blood-brain barrier, and changes in gene expression can
… entry to neuronal dysfunction and death is through mitochondrial dysfunction. Mitochondria …

Blood–brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

N Marchi, T Granata, C Ghosh, D Janigro - Epilepsia, 2012 - Wiley Online Library
… DWI-T 2 and ADC signals were increased in the left temporoparietal area in a case of partial
status epilepticus characterized by repetitive right focal motor seizures. The localization of …

Blood–brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?

A Friedman - Epilepsia, 2011 - Wiley Online Library
dysfunction and increased vessels permeability. We discuss here the direct role of blood–brain
barrier (BBB) dysfunction in epileptogenesis and brain … presence of dysfunctional BBB, …

[HTML][HTML] Time-and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus

PN Bernardino, BA Hobson, SL Huddleston… - Neurobiology of …, 2023 - Elsevier
Acute organophosphate (OP) intoxication can trigger seizures that progress to status epilepticus
(SE), and survivors often develop chronic morbidities, including spontaneous recurrent …

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis

G Bar-Klein, S Lublinsky, L Kamintsky, I Noyman… - Brain, 2017 - academic.oup.com
… -injury epilepsy is critically required. Microvascular pathology and related blood–brain barrier
dysfunction … follow blood–brain barrier pathology in rats following status epilepticus, late …

Status epilepticus increases CSF levels of neuron-specific enolase and alters the blood-brain barrier

J Correale, AL Rabinowicz, CN Heck, TD Smith… - Neurology, 1998 - AAN Enterprises
… Human studies described in vivo BBB dysfunction in patients undergoing a single seizure
… Our data demonstrate in vivo that after SE, there is a marked dysfunction of the BBB as …

Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia

R Kovács, U Heinemann, C Steinhäuser - Epilepsia, 2012 - Wiley Online Library
… also contributing to neurologic disorders such as epilepsy. Activated astrocytes are … epilepsy
and Ammon′s horn sclerosis. Blood–brain barrier (BBB) opening during status epilepticus

Blood–brain barrier damage and new onset refractory status epilepticus: An exploratory study using dynamic contrast‐enhanced magnetic resonance imaging

H Li, X Liu, R Wang, A Lu, Z Ma, S Wu, H Lu, Y Du… - …, 2023 - Wiley Online Library
… a model of acquired epilepsy following blood- b rain barrier dysfunction. Neurobiol … Status
epilepticus increases CSF levels of neuronspecific enolase and alters the blood– b rain barrier