… Due to limitations, no single in vitro assay will ever be able to detect developmental
toxicants with 100% accuracy. Thus, it is critical that assay limitations are acknowledged and …

… Currently, there is no clear consensus among research communities on how to measure
the efficacy or accuracy of individual developmental toxicity assays in a comparable manner. …

… Stem Cell Initiative compared several commonly used approaches to assess human pluripotent
stem cells … of the transcriptomes of undifferentiated cells, whereas, embryoid body (EB) …

… of unknown potential for developmental toxicity, an … developmental toxicity studies. The new
assay identified the potential developmental toxicants in the test set with 77% accuracy (57% …

… Developmental origin of pluripotent embryonic stem cell … and developmental biology, this
review focuses mainly on … applications of mouse and human ES cells for stem cell research. …

… Developmental potency is reduced with each step, which means that a unipotent stem cell is
not … These stem cells appear to provide an accurate paradigm model system to study tissue-…

… In this review, the current state of three in vivo developmental toxicity assays commonly in …
embryo-larva developmental toxicity assay and the mouse embryonic stem cell test (EST). This …

… Studies done by using various types of pluripotent cells indicated that pluripotency is more
accurately defined as a transient and dynamic state in vitro and different types of PSCs can be …

… , functionality of the differentiated cells and changes in … progression or disruption of stem cell
differentiation. To illustrate … technology to accurately identify developmental toxicity hazards …

… cells are very suitable for embryotoxicity assessment as they have been demonstrated to
specify cellular developmental … of differentiation to functionally competent specialized cell types. …