… This cell may be an actively dividing stem cell, a stem cell … an a differentiated (mature) cell
acquiring the property of self-… strategies to directly target the growth of tumor stem cells can …

… BMI1 is also required for the maintenance of neural stem cells 67 and leukemic stem
cells 68 , indicating that it has a broad role in stem-cell maintenance. Loss of HSCs in BMI1-…

… For instance, Paneth cells located in intestinal crypts and melanocyte stem cells located in
… intestinal stem cells and hair follicle stem cells, respectively.29, 30 Cancer stem cells have …

… stem cells (MSCs)are hierarchical postnatal stem cells, capable … They can activate other
resident stem cells and stimulate neo-… for the clinical treatment of some human diseases. As yet, …

… for the treatment of different … of stem cells differ, the therapeutic effects of stem cells that
are recognized by the current research are mainly manifested in three aspects. First, stem cells …

In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their ability
to undergo differentiation toward cells of different lineages. More recently, a major …

… In this review, we summarize the therapeutic strategies for targeting CSCs in several … some
of them are being tested in clinical trials, a clear treatment strategy has not been developed. …

… have great advantages on cancer treatment, several issues need … cell surface markers exist
in CSCs and normal stem cells are the same, how do we avoid destroying normal stem cells …

… stem cells are also not targeted. Conversely, treatments that selectively attack cancer stem
cells will not immediately eliminate the differentiated cancer cells, and might therefore be …

… of cancer cells that have the stem cell properties … stem cell niche is required for determining
stem cell fate, as the behaviour of stem cells is influenced by their association with other cells …