M Thoms, R Buschauer, M Ameismeier, L Koepke… - Science, 2020 - science.org
… 3×FLAG-tagged Nsp1 of SARS-CoV-2 and SARS-CoV and their respective mutants in … In summary, Nsp1 from both SARS-CoV and SARS-CoV-2 binds 40S and 80S ribosomes …
Q Peng, R Peng, B Yuan, M Wang, J Zhao, L Fu, J Qi… - The Innovation, 2021 - cell.com
… Also, we provide the structuralbasis of Favipiravir recognition by the SARS-CoV-2 polymerase complex and discuss the mechanism of catalysis by this particular polymerase. …
… -2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that … structural snapshot describes the structuralbases underlying the pandemic capacity of SARS-CoV-…
W Yin, C Mao, X Luan, DD Shen, Q Shen, H Su… - Science, 2020 - science.org
… Here we report the cryo–electron microscopy structure of the SARS-CoV-2 RdRp, both in … -base template-primer RNA and remdesivir at 2.5-angstrom resolution. The complex structure …
Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
… caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in … neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at …
H Sivaraman, SY Er, YK Choong… - Annual Review of …, 2021 - annualreviews.org
… In this article, we have presented our analysis of the structuralbasis for SARS-CoV/CoV-2/MERS–receptor interactions and the potential for small-molecule inhibitors as therapeutics. …
SE Greasley, S Noell, O Plotnikova, RA Ferre… - Journal of Biological …, 2022 - ASBMB
… SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the main protease (M pro ) of SARS-CoV… is underdetermined against evolving SARS-CoV-2 variants…
… Rapid progress in structural biology of the S protein has advanced our knowledge of the SARS-CoV-2 entry process (15–28). We have previously identified two structural elements, the …
… correction during SARS-CoV-2 RNA synthesis and reveals the structural features in the substrate that are essential for ExoN recognition and catalysis, providing a basis for structural-…