[HTML][HTML] Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

MT ul Qamar, SM Alqahtani, MA Alamri… - Journal of pharmaceutical …, 2020 - Elsevier
… conducted to gain structural insights into the SARS-CoV-2 … We predicted the 3D structure of
the SARS-CoV-2 3CL pro … similarity with the SARS-CoV 3CL pro structure, the SARS-CoV-2 …

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

M Thoms, R Buschauer, M Ameismeier, L Koepke… - Science, 2020 - science.org
… 3×FLAG-tagged Nsp1 of SARS-CoV-2 and SARS-CoV and their respective mutants in …
In summary, Nsp1 from both SARS-CoV and SARS-CoV-2 binds 40S and 80S ribosomes …

Structural basis of SARS-CoV-2 polymerase inhibition by favipiravir

Q Peng, R Peng, B Yuan, M Wang, J Zhao, L Fu, J Qi… - The Innovation, 2021 - cell.com
… Also, we provide the structural basis of Favipiravir recognition by the SARS-CoV-2
polymerase complex and discuss the mechanism of catalysis by this particular polymerase. …

The structural basis of accelerated host cell entry by SARSCoV‐2

M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
… -2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that …
structural snapshot describes the structural bases underlying the pandemic capacity of SARS-CoV-…

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

W Yin, C Mao, X Luan, DD Shen, Q Shen, H Su… - Science, 2020 - science.org
… Here we report the cryo–electron microscopy structure of the SARS-CoV-2 RdRp, both in …
-base template-primer RNA and remdesivir at 2.5-angstrom resolution. The complex structure

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
… caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in
… neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at …

Structural basis of SARS-CoV-2–and SARS-CoV–receptor binding and small-molecule blockers as potential therapeutics

H Sivaraman, SY Er, YK Choong… - Annual Review of …, 2021 - annualreviews.org
… In this article, we have presented our analysis of the structural basis for SARS-CoV/CoV-2/MERS–receptor
interactions and the potential for small-molecule inhibitors as therapeutics. …

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

SE Greasley, S Noell, O Plotnikova, RA Ferre… - Journal of Biological …, 2022 - ASBMB
SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the main
protease (M pro ) of SARS-CoV… is underdetermined against evolving SARS-CoV-2 variants…

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Y Cai, J Zhang, T Xiao, CL Lavine, S Rawson, H Peng… - Science, 2021 - science.org
… Rapid progress in structural biology of the S protein has advanced our knowledge of the
SARS-CoV-2 entry process (15–28). We have previously identified two structural elements, the …

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme

C Liu, W Shi, ST Becker, DG Schatz, B Liu, Y Yang - Science, 2021 - science.org
… correction during SARS-CoV-2 RNA synthesis and reveals the structural features in the
substrate that are essential for ExoN recognition and catalysis, providing a basis for structural-…