… structures of two human monoclonal antibodies–AZD8895 and AZD1061–which form the basis … domain (RBD) of SARS-CoV-2 to define the genetic and structuralbasis of neutralization. …
T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
… Our study reveals the structuralbasis by which select RBD-directed antibodies such as S2E12 … Structuralbasis for potent neutralization of B.1.1.529 by monoclonal antibodies and their …
W Zhang, K Shi, Q Geng, G Ye… - Proceedings of the …, 2022 - National Acad Sciences
… structures from the SARS-CoV-1 RBD and hACE2 and varies the noncrystal contact regions involving the RBM of SARS-CoV-2 … structure from SARS-CoV-1 RBD and the RBM from the …
DC Dinesh, D Chalupska, J Silhan, E Koutna… - PLoS …, 2020 - journals.plos.org
… β2-β3 that forms a long basic β-hairpin (β2' and β3') (… basic amino acid residues therefore we refer to it as a basic finger (Fig 2C). This basic finger is extending from the β-core structure …
The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A, from an …
PR Bhatt, A Scaiola, G Loughran, M Leibundgut… - Science, 2021 - science.org
… respiratory syndrome coronavirus 2 (SARS-CoV-2… structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure …
Y Zhao, Y Zhu, X Liu, Z Jin, Y Duan… - Proceedings of the …, 2022 - National Acad Sciences
… the structuralbasis for replicase polyprotein cleavage and substrate specificity of SARS-CoV… Through analyzing a series of high-resolution structures of SARS-CoV-2 M pro throughout …
W Yin, X Luan, Z Li, Z Zhou, Q Wang, M Gao… - Nature structural & …, 2021 - nature.com
… The structure of the RdRp–suramin complex For the cryo-EM studies, we incubated the SARS-CoV-2 RdRp complex with tenfold molar excess of suramin (Methods). The structure was …
J Chen, B Malone, E Llewellyn, M Grasso… - Cell, 2020 - cell.com
… SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 … Here we present cryoelectron microscopic structures of the SARS-CoV-2 holo-RdRp with an …