[HTML][HTML] Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

S Sun, H Gu, L Cao, Q Chen, Q Ye, G Yang… - Nature …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV… similar to those of SARS-CoV and MERS-CoV infections, ranging from …

[HTML][HTML] Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr… - Nature …, 2021 - nature.com
structures of two human monoclonal antibodies–AZD8895 and AZD1061–which form the basis
… domain (RBD) of SARS-CoV-2 to define the genetic and structural basis of neutralization. …

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529

T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
… Our study reveals the structural basis by which select RBD-directed antibodies such as S2E12
Structural basis for potent neutralization of B.1.1.529 by monoclonal antibodies and their …

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

W Zhang, K Shi, Q Geng, G Ye… - Proceedings of the …, 2022 - National Acad Sciences
structures from the SARS-CoV-1 RBD and hACE2 and varies the noncrystal contact regions
involving the RBM of SARS-CoV-2 … structure from SARS-CoV-1 RBD and the RBM from the …

[HTML][HTML] Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

DC Dinesh, D Chalupska, J Silhan, E Koutna… - PLoS …, 2020 - journals.plos.org
… β2-β3 that forms a long basic β-hairpin (β2' and β3') (… basic amino acid residues therefore
we refer to it as a basic finger (Fig 2C). This basic finger is extending from the β-core structure

[HTML][HTML] Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D Zhou, HME Duyvesteyn, CP Chen… - Nature structural & …, 2020 - nature.com
The COVID-19 pandemic has had an unprecedented health and economic impact and
there are currently no approved therapies. We have isolated an antibody, EY6A, from an …

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

PR Bhatt, A Scaiola, G Loughran, M Leibundgut… - Science, 2021 - science.org
… respiratory syndrome coronavirus 2 (SARS-CoV-2… structure of a translating mammalian
ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2

Y Zhao, Y Zhu, X Liu, Z Jin, Y Duan… - Proceedings of the …, 2022 - National Acad Sciences
… the structural basis for replicase polyprotein cleavage and substrate specificity of SARS-CoV
Through analyzing a series of high-resolution structures of SARS-CoV-2 M pro throughout …

[HTML][HTML] Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

W Yin, X Luan, Z Li, Z Zhou, Q Wang, M Gao… - Nature structural & …, 2021 - nature.com
… The structure of the RdRp–suramin complex For the cryo-EM studies, we incubated the
SARS-CoV-2 RdRp complex with tenfold molar excess of suramin (Methods). The structure was …

[HTML][HTML] Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

J Chen, B Malone, E Llewellyn, M Grasso… - Cell, 2020 - cell.com
SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 …
Here we present cryoelectron microscopic structures of the SARS-CoV-2 holo-RdRp with an …