Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells

HE Lee, JY Lee, G Yang, HC Kang, YY Cho, HS Lee… - Scientific reports, 2019 - nature.com
… promotion of tumor cell metastasis. Celastrol, an inhibitor of NLRP3 inflammasome, reduces
… inhibitors of NLRP3 inflammasome would suppress metastatic potential of cancer cells. We …

The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity

J Dupaul-Chicoine, A Arabzadeh, M Dagenais… - Immunity, 2015 - cell.com
… We assessed cell proliferation potential in metastatic foci on days 14 and 21 pi by
immunofluorescence staining of liver tissue sections with antibodies against proliferating cellular …

Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome

I Ahmad, KM Muneer, IA Tamimi, ME Chang… - Toxicology and applied …, 2013 - Elsevier
… of metastasis by inhibition of NLRP3 inflammasome. In this present investigation, we have
demonstrated the anti-metastatic potential … of a new molecular target, NLRP3 inflammasome. …

Targeting the NLRP3 inflammasome as a new therapeutic option for overcoming cancer

S Missiroli, M Perrone, C Boncompagni, C Borghi… - Cancers, 2021 - mdpi.com
potential of targeting NLRP3 for cancer therapy, emphasizing how understanding NLRP3
inflammasome-… Intriguingly, the NLRP3 inflammasome suppresses CRC metastatic growth …

[HTML][HTML] Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-κB pathway

J Zou, Y Yang, Y Yang, X Liu - Biomedicine & Pharmacotherapy, 2018 - Elsevier
metastasis of various tumor cells [[11], [12], [13]]. Therefore, NLRP3 inflammasome might be
a potential … observed that polydatin suppressed the proliferation and metastasis of NSCLC …

Diverging inflammasome signals in tumorigenesis and potential targeting

R Karki, TD Kanneganti - Nature Reviews Cancer, 2019 - nature.com
… of NLRP3 inflammasome assembly. Non-canonical NLRP3 inflammasome activation …
a suppressive function is inert in metastatic melanoma cells. Instead, ASC contributes to an …

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma

Z Zhai, W Liu, M Kaur, Y Luo, J Domenico, JM Samson… - Oncogene, 2017 - nature.com
… We have reported that NLRP3 inflammasomes are constitutively activated and mediate …
To investigate the potential functional roles of NLRP1 in melanoma, we knocked down NLRP1 …

Alpinumisoflavone suppresses hepatocellular carcinoma cell growth and metastasis via NLRP3 inflammasome-mediated pyroptosis

Y Zhang, H Yang, M Sun, T He, Y Liu, X Yang… - Pharmacological …, 2020 - Springer
… In colorectal cancer, AIF is reported to suppress tumor growth and metastasis by blocking …
and suppress the metastatic potential of HCC cell by triggering NLRP3 inflammasome-…

Role of the NLRP3 inflammasome: insights into cancer hallmarks

TY Lin, MC Tsai, W Tu, HC Yeh, SC Wang… - Frontiers in …, 2021 - frontiersin.org
… , greatly diminished and the metastatic potential of melanoma tumor cells was suppressed
(26). Mediating immune-suppressive crosstalk, NLRP3 signaling in macrophages has been …

NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver

Q Deng, Y Geng, L Zhao, R Li, Z Zhang, K Li, R Liang… - Cancer letters, 2019 - Elsevier
… The NLRP3 inflammasome was activated in MΦs by MΦ–CRC cell crosstalk; it resulted
in … NLRP3 signaling suppressed CRC cell migration in vitro, and metastatic ability in vivo. …