[HTML][HTML] Nutraceutical strategies for suppressing NLRP3 inflammasome activation: pertinence to the management of COVID-19 and beyond

MF McCarty, SB Iloki Assanga, L Lewis Luján… - Nutrients, 2020 - mdpi.com
… and IFI16 inflammasomes [4]. This review focuses on the NLRP3 inflammasome, which has
… Not surprisingly, ferulic acid has been found to suppress NLRP3-dependent inflammasome

[HTML][HTML] Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes

Y Kim, W Wang, M Okla, I Kang, R Moreau… - Journal of lipid …, 2016 - ASBMB
NLRP3 inflammasome activation and attendant consequences on type 2 diabetes. γT3
repressed inflammasome … , implicating the inhibition of NLRP3 inflammasome in the anti-…

Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: a review

M Olcum, B Tastan, I Ercan, IB Eltutan, S Genc - Phytomedicine, 2020 - Elsevier
… RSV treatment decreased TXNIP expression and thereby suppressed NLRP3 inflammasome
activation. RSV exerts a protective effect against cadmium-induced nephrotoxicity through …

[HTML][HTML] Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells

HE Lee, JY Lee, G Yang, HC Kang, YY Cho, HS Lee… - Scientific reports, 2019 - nature.com
… of NLRP3 inflammasome would suppresssuppressed the activation of NLRP3 inflammasome
induced by ATP or nigericin. Celastrol inhibited the activation of NLRP3 inflammasome

Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation

G Yang, SH Yeon, HE Lee, HC Kang, YY Cho… - …, 2018 - academic.oup.com
… Previously, we reported that the suppression of the NLRP3 inflammasome by SFN was
mediated by the regulation of the AMP-activated protein kinase-autophagy axis in hepatocytes [17…

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

JK Kim, HS Jin, HW Suh, EK Jo - Immunology and Cell Biology, 2017 - Wiley Online Library
… Furthermore, fluoxetine suppresses NLRP3 inflammasome activation in macrophages and
the hippocampus in chronic mild-stress mice, suggesting a promising therapeutic role for …

[HTML][HTML] NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma

F Lu, Y Zhao, Y Pang, M Ji, Y Sun, H Wang, J Zou… - Cancer Letters, 2021 - Elsevier
… The NLRP3 inflammasome plays a pro-tumorigenic role in … Furthermore, NLRP3 inflammasome
activation in DLBCL cell … NLRP3 inflammasome blockade in vivo suppressed lymphoma …

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

F Marín‐Aguilar, AV Lechuga‐Vieco… - Aging cell, 2020 - Wiley Online Library
… However, the role of the NLRP3 inflammasome in lifespan and cardiac aging has not been
studied. Hence, we sought to determine whether or not genetic deletion of NLRP3 may have …

Curcumin suppresses IL-1β secretion and prevents inflammation through inhibition of the NLRP3 inflammasome

H Yin, Q Guo, X Li, T Tang, C Li, H Wang… - The Journal of …, 2018 - journals.aai.org
… mechanisms that control NLRP3 inflammasome deactivation may … inflammasome activity.
In this study, we found that curcumin suppressed inflammation via strong inhibition of NLRP3-…

[HTML][HTML] Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

K Mao, S Chen, M Chen, Y Ma, Y Wang, B Huang, Z He… - Cell research, 2013 - nature.com
… Nitric oxide suppresses NLRP3 inflammasome-mediated IL-… To investigate the effect of NO
on NLRP3 inflammasome … ATP, an activator of the NLRP3 inflammasome, in the presence of …