Sustainability has increasingly become a growing concern for consumers, businesses, governments and communities. In recent years, mounting regulatory pressures, scarcity of natural resources, and increased population and urban growth have prompted companies to remain competitive and continuously deliver new products and services in today’s marketplace. There have also been increased levels of waste, and growing demands from customers and stakeholders. Due to these issues, companies develop efficient and sustainable supply chain operations to gain positive results and uncover monetary benefits. The purpose of this study is to analyze various challenges and trends affecting the global supply chain and logistics. The study recognizes several sustainable supply chain management practices and initiatives and focuses on the economic, environmental and social impacts. In addition, the study provides some key measures and recommendations for organizations to adopt a sustainable supply chain operation. The findings were developed and evaluated based on journal readings, literature review studies, textbooks and articles. The unique synergies between sustainable supply chain versus traditional logistical and supply chain practices have been instrumental by incorporating the triple-bottom line theory within the organization’s logistics and supply chain operation. Companies must continually adapt to change and anticipate unforeseeable current and future challenges. Sustainability will not only support organizations to sustain their supply chain operations, but they will be able to further sustain the world’s business environment for better living and economic prosperity.