… an involvement of synapse biology, primarily intracellular signal transduction and synapse
excitability. These findings suggest an important role of synaptic processes in excitatory and …

… For distinct genomic loci, we combined all loci that were … the lead SNP of the combined
locus. LD calculations utilized the … Mapping genomic loci implicates genes and synaptic biology …

… , identified from the biological pathways affected by risk loci and from neuroimaging studies
(… , synaptic plasticity and neurodevelopment. First, we present the basic biological definitions …

… of the biological knowledge, beginning to emerge from the intricate genomic background …
the interpretation of significant associations in a genomic locus can be. Since the discovery …

… 2 locus relative to all regions of the genome and gene content per module, the rank of the
22q11.2 locus was compared to the empirical distribution from all equal-sized genomic regions…

… The ML-based GWAS also identified 93 novel loci, significantly … the biological significance
of the novel hits to VCDR: select loci near genes involved in neuronal and synaptic biology or …

… early phase of learning and are linked to synaptic plasticity loci. It is interesting to note that
… to detect the specific signatures of individual siRNAs associated with synaptic plasticity loci. …

… of the Psychiatric Genomics Consortium, Ripke, S., Walters, JT, & O’Donovan, MC (2020).
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. …

… Our study is underpowered to detect individual loci of rare TREs associated with schizophrenia
at genome-wide significance (Supplementary Fig. 8). We compared the individual rare …

… against Synaptophysin (pre-synaptic protein) and PSD95 (post-synaptic protein). We found
… flailer genomic locus, resulting in a reduction of its expression that can rescue the synaptic …