Genetic architectures of psychiatric disorders: the emerging picture and its implications

PF Sullivan, MJ Daly, M O'donovan - Nature Reviews Genetics, 2012 - nature.com
… that many of the 81 top loci include true risk loci but that power was … 34 statistically independent
loci in around 4,500 cases. Two … hypotheses, such as synaptic biology for SCZ and ASD. …

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

M Ahangari, E Everest, TH Nguyen, BC Verrelli… - Brain, Behavior, and …, 2022 - Elsevier
… Follow-up functional analysis of the shared loci implicates candidate genes and biological
processes involved in immune response and B-cell receptor signaling pathways. In conclusion…

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

JE Savage, PR Jansen, S Stringer, K Watanabe… - Nature …, 2018 - nature.com
… to nervous system development and synaptic structure. We confirm … of variants in the associated
genomic loci is presented in … and gene mapping using biological data resources provide …

[PDF][PDF] Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

E Markenscoff-Papadimitriou, F Binyameen, S Whalen… - Cell reports, 2021 - cell.com
… binds euchromatic regions of the genome and acts to promote … À/À are arrayed in gene
clusters and encode synapse and … POGZ and ADNP co-occupy genomic loci and we provide …

Genetic contributions to autism spectrum disorder

A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
… of the Psychiatric Genomics Consortium., Ripke, S., Walters, JT, & O’Donovan, MC (2020).
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. …

[PDF][PDF] Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability

D Ruano, GR Abecasis, B Glaser, ES Lips… - The American Journal of …, 2010 - cell.com
… , from single-locus analysis to genome-wide association … of synaptic genes was associated
with cognitive ability, we tested four biological pathways that are known to involve synaptic

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
… the contributions of different biological and technical variables on genome-wide CpG DNAm
… Overall, these gDMRs were in or near genes enriched for GO terms related to synapse and …

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

M Kim, JR Haney, P Zhang, LM Hernandez… - Nature …, 2021 - nature.com
… We then sought to understand the biological pathways and cell types captured by these
C4A… of these complement components to genome-wide significant loci from two recent SCZ …

Convergence of placenta biology and genetic risk for schizophrenia

G Ursini, G Punzi, Q Chen, S Marenco, JF Robinson… - Nature medicine, 2018 - nature.com
… The gene set composed of schizophrenia loci that interact … orthogonal biological processes
(for example, synaptic function). … analyses of schizophrenia loci, such as synaptic function, …

Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission

K Askland, C Read, J Moore - Human genetics, 2009 - Springer
… Seventy genes contribute to the significance of the synaptic … Thus, the appearance of
synaptic transmission as a … a role for heterogeneous loci within this biological pathway. …