… associated with variants most strongly linked to illness risk. We show that the schizophrenia
loci are strongly linked to synaptic transmission ( P FWE < .001) and ion transmembrane …

… To test whether synaptic functional groups contained … all significant loci reported in GWA
studies for schizophrenia that … the synaptic functional groups included genes for schizophrenia …

… and confirm a substantial polygenic component of risk for the disorder (6, 12, … loci have roles
in plasticity and synaptic function, this link is not so clear for many of the other associated loci…

… The diversity of synaptic proteins identified in this study suggests multiple functional
interactions of schizophrenia risk converging on synapses. It remains to be determined whether …

… schizophrenia begin in utero but continue throughout development, with some alleles conferring
risk to the disorder through direct effects on synaptic function … association study risk loci (…

… ) controls neuronal activity and thereby maintains synaptic functioning and development.
Gene deletions in PLC are associated with schizophrenia and altered expression of Plc and …

… Finally, although this study was designed to test the relevance of genetic risk loci related
to synaptic function as a potential biological mechanism of cognitive disability in SZ, this …

… synaptic proteins identified in this study suggests that multiple functional interactions of
schizophrenia risk … Genome-wide association analysis identifies 13 new risk loci for schizophrenia…

… that schizophrenia and bipolar disorder and several other psychiatric disorders share risk
loci … These 3 genes also have important roles in synaptic function (Fig. 1): NF1 is a key …

… First, we correlated the risk allele to expression of the genes in the MIR137 locus in human
… in synaptic transmission upon miR-137 overexpression. Evoked synaptic transmission and …