The role of drug transporters at the blood-brain barrier

AG De Boer, ICJ Van Der Sandt… - Annual review of …, 2003 - annualreviews.org
… Until now, many transport systems have been discovered that play an … and brain homeostasis.
In this review, wefocus on the role of carrier- and receptor-mediated transport systems (…

Brain interstitial fluid glutamine homeostasis is controlled by bloodbrain barrier SLC7A5/LAT1 amino acid transporter

E Dolgodilina, S Imobersteg, E Laczko… - … of Cerebral Blood …, 2016 - journals.sagepub.com
… of system L and N transporters in GABA ISF homeostasis (supplementary Table 3). Finally,
at no time did any of the competitive inhibitor perfusions produce observable behavioral …

The bloodbrain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
… The various transport systems thus play a critical role in brain homeostasis. Although the
list of transporters is ever expanding, it appears that they can be conveniently classified into …

Transcytosis at the bloodbrain barrier

S Ayloo, C Gu - Current opinion in neurobiology, 2019 - Elsevier
… The bloodbrain barrier (BBB) is a functional interface separating the brain from the circulatory
system and is essential for homeostasis of the central nervous system (CNS). The BBB …

Immune dynamics in the CNS and its barriers during homeostasis and disease

MW Buckley, DB McGavern - Immunological reviews, 2022 - Wiley Online Library
barriers including the skull, meninges, bloodbrain barrier (BBB), blood–CSF barrier,
CSF–interstitial fluid barrier, … CNS immune system regulates neural activity during homeostasis

Overview and introduction: the bloodbrain barrier in health and disease

NJ Abbott, A Friedman - Epilepsia, 2012 - Wiley Online Library
… This article introduces the special issue on ‘‘BloodBrain Barrier … sites protecting the central
nervous system (CNS). The … BBB are key to brain homeostasis. It is now recognized that the …

The bloodbrain barrier

B Obermeier, A Verma, RM Ransohoff - Handbook of clinical neurology, 2016 - Elsevier
… allow for maintenance of brain homeostasis, regulation of … blood–cerebrospinal fluid
barrier,” situated at the choroid plexuses within the brain ventricular system, separating the brain

[PDF][PDF] Current concepts of blood-brain barrier development

S Liebner, CJ Czupalla, H Wolburg - International Journal of …, 2011 - researchgate.net
… ABSTRACT Homeostasis of the central nervous system (CNS) microenvironment is essential
for its normal function and is maintained by the blood-brain barrier (BBB). The BBB proper …

Tight junctions of the bloodbrain barrier: development, composition and regulation

H Wolburg, A Lippoldt - Vascular pharmacology, 2002 - Elsevier
… appears to be similar in all barrier systems, regardless of some … the development of the
bloodbrain barrier, the composition … homeostasis of the brain and the maintenance of the blood–…

[PDF][PDF] Physiology and pharmacological role of the blood-brain barrier

J Bernacki, A Dobrowolska, K Nierwiñska, A Malecki - Pharmacol rep, 2008 - Citeseer
… Due to all of these facts, the BBB is the most significant element responsible for the preservation
of CNS homeostasis. As a functional system, the BBB can be investigated as a frontier …