… the blood–brain barrier (BBB), which plays a critical role in maintaining the brain homeostasis
… to accelerate the development of novel central nervous system (CNS) drug therapies and …

… The blood-brain barrier is a dynamic interface between the blood and the central nervous
system (… integrity of the BBB is vital to maintain the homeostasis of the brain microenvironment. …

… The barrier also plays an important role in the homeostatic regulation of the … In the
central nervous system mice lacking AQP4 are partially protected from brain oedema in water …

… for the development and homeostasis of the central nervous system, which is insulated from
… the blood–brain barrier. Local insulin/IGF signalling from glial cells, the blood–brain barrier …

… in blood–brain barrier integrity and regulation. We also address pitfalls of existing systems
… These types of edema alter the homeostasis of the brain, leading to fluid accumulation. As …

… The three brain barriers include the arachnoid barrier, blood-cerebrospinal fluid barrier, and
… and the central nervous system, is a highly selective semipermeable structural and chemical …

… vitamins) through its intricate vascular system, which comprises of cerebral blood vessels that
are … and inner CSF and brain tissue, performing homeostatic and neurosecretory functions. …

… The blood brain barrier is constituted by brain endothelial cells, astroglia, pericytes and
microglia; in addition it includes two specialized extracellular matrix components, the basal …

… We review work showing that the BBB is a dynamic system, and discuss the ways in which
BBB … and brain metabolites, further aiding homeostasis of the brain microenvironment 5 . …

… The BBB serves to protect the brain by maintaining CNS homeostasis and keeping toxic
materials out of this privileged compartment. Achieving effective drug concentrations within the …