… , we aimed to establish a clinical target in the management of knee osteoarthritis (KOA) and
to propose good clinical practice (GCP) statements for carrying out a treat-to-target strategy. …

… There is still no definitive treatment for knee osteoarthritis (OA). We are … of treatment or on
an effective treatment recommendation. There are reasons for the current equivocal treatment …

… Wnt-targeting therapeutic strategies. Indeed, previous strategies targeting members of the
Wnt … patients, compared with placebo treatment, lorecivivint treatment did not meet the primary …

… The hydration lubrication mechanism provides a framework for designing very efficient
boundary lubrication systems, which relate to articular cartilage as the target in OA treatment. …

… this challenge by suggesting that it is time to develop a “treat to target strategy” for KOA. …
-to-target strategy. Until then, our focus can be directed to treat-to-target strategy for KOA similar …

… potential functions for the targeted treatment of arthritis. This … system in the treatment of
osteoarthritis from three aspects: (1… to treat OA, (2) the construction of osteoarthritis models, and (3…

… The targeting of specific sites of inflammation could cause potential side effects, as has
been shown in targeted strategies for RA [52,55]. Most of the processes of inflammation are of …

… treatment options led to the development of strategies that … and bone defects or targeted
pro-inflammatory mediators by … and controlled release of treatments in the target joints. Confining …

… This article provides an overview of targeted … treatments and other methods to inhibit IL-1β-induced
MMPs and inflammatory mediators constitutes a rational strategy for treating OA [47]. …

… This review will focus on emerging strategies based on novel … Since these current treatment
options are lacking efficacy for … Preclinical studies indicate that MMP-13 is a crucial target for …