Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… trigger life-threatening “cytokine storms” in the host … inflammatory immune responses may
improve outcome. We review some of the current candidates for treatment of cytokine storms

Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

R Hirawat, MA Saifi, C Godugu - Life sciences, 2021 - Elsevier
… Clinical studies suggest excessive release of inflammatory mediators leads to cytokine storm,
a … The review also portrays a question and debates: Can targeting cytokine storm can be a …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… -inflammation and cytokine storm highlights the necessity of early identification of
cytokine storm and implementation of anti-inflammatory treatment. Timely control of hyper-inflammatory

Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm

N Morgulchik, F Athanasopoulou, E Chu… - Interface …, 2021 - royalsocietypublishing.org
Targeting various pro-inflammatory cytokines in a specific manner … cytokine storm, and
this review will summarize and discuss advances in targeted therapies against cytokine storms

Targeting cytokine storm to manage patients with COVID-19: a mini-review

N Roshanravan, F Seif, A Ostadrahimi… - Archives of medical …, 2020 - Elsevier
… In this mini-review, we addressed the inflammatory pathways of the severe acute … host
cytokine storm. Furthermore, the proposed therapeutic options to reverse hyper-inflammation in …

COVID-19 cytokine storm: targeting the appropriate cytokine

RQ Cron - The Lancet Rheumatology, 2021 - thelancet.com
… to dampen the cytokine storm syndrome to … cytokine storm syndrome was targeting interleukin-6
(IL-6). Early during the pandemic, IL-6 concentrations were noted to be elevated, and IL-6

Cytokine storm and sepsis disease pathogenesis

BG Chousterman, FK Swirski, GF Weber - Seminars in immunopathology, 2017 - Springer
… clinical trials targeting cytokine production or effects failed. This review aims to summarize
the pathophysiology of the cytokine storm; to describe the type, effects, and kinetics of cytokine

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … transduction and targeted …, 2021 - nature.com
… , cytokine storm (CS). The CS is characterized by hyperproduction of an array of pro-inflammatory
cytokines … pro-inflammatory cytokines initiate different inflammatory signaling pathways …

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

D Panigrahy, MM Gilligan, S Huang, A Gartung… - Cancer and metastasis …, 2020 - Springer
… ), which also stimulate inflammation resolution by promoting … anti-inflammatory processes,
and preventing the cytokine storm. … Targeting individual pro-inflammatory cytokines may not be …

[HTML][HTML] Nanomedicine therapies modulating macrophage dysfunction: a potential strategy to attenuate cytokine storms in severe infections

J Liu, M Wan, CJ Lyon, TY Hu - Theranostics, 2020 - ncbi.nlm.nih.gov
… macrophage-targeted nanomedicines can be employed to attenuate cytokine storms and …
or other conditions associated with excessive pro-inflammatory responses. We also discuss …