Using human genetics to understand the disease impacts of testosterone in men and women

KS Ruth, FR Day, J Tyrrell, DJ Thompson, AR Wood… - Nature medicine, 2020 - nature.com
… , we identified genetic determinants of testosterone levels … genetic determinants of testosterone
levels are substantially different between sexes and that genetically higher testosterone

Genetic determinants of serum testosterone concentrations in men

C Ohlsson, H Wallaschofski, KL Lunetta, L Stolk… - … genetics, 2011 - journals.plos.org
genetic variants on serum testosterone concentrations. By examining 14,429 men, we
show that genetic … variation in serum testosterone concentrations and increased risk of low …

Genetics of sex hormone-binding globulin and testosterone levels in fertile and infertile men of reproductive age

M Grigorova, M Punab, O Poolamets… - Journal of the …, 2017 - academic.oup.com
men with genetically inherited low FSH [3]. Other examples of extensively analyzed variants
in andrology settings have smaller genetic … androgenic hormone in men is testosterone (T). …

Genetic analysis reveals role of testosterone levels in human disease.

C Greenhill - Nature Reviews Endocrinology, 2020 - go.gale.com
… "We have shown that testosterone levels in men and women are heritable (~20%) and …
many genetic variants and genes," says Perry. Notably, the genetic determinants of testosterone

[HTML][HTML] Genetic susceptibility for low testosterone in men and its implications in biology and screening: data from the UK biobank

RJ Fantus, R Na, J Wei, Z Shi, WK Resurreccion… - European Urology Open …, 2021 - Elsevier
genetic loci that can be incorporated into a genetic risk score that can potentially identify
men with low testosterone… some comorbidities and testosterone, men with the confounding …

[HTML][HTML] Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: a Mendelian randomization investigation

CM Schooling, S Luo, SLA Yeung… - International journal of …, 2018 - Elsevier
… Finally, the weights in the gene scores for testosterone were derived in men only. Although
… causality as comprehensively as possible using human genetics. Further biological insight of …

SNPs associated with testosterone levels influence human facial morphology

J Roosenboom, K Indencleef, MK Lee… - … in genetics, 2018 - frontiersin.org
… circulating sex hormone levels in humans, which we hypothesize, … testosterone-related
genetic variants on facial morphology. We tested 32 genetic variants across 22 candidate genes

Genetics of testosterone and the aggression-hostility-anger (AHA) syndrome: a study of middle-aged male twins

F Sluyter, JN Keijser, DI Boomsma… - … and Human Genetics, 2000 - cambridge.org
… levels in youngadult twins (13–21 years) from the same twin registry we used, and found
that 66% of the variance in testosterone concentrations in young-adult men can be accounted …

Genomic predictors of testosterone levels are associated with muscle fiber size and strength

JPLF Guilherme, EA Semenova, OV Borisov… - European Journal of …, 2022 - Springer
… towards identifying the shared genetic background between testosterone-increasing alleles,
… change in lean mass per unit higher of testosterone (bioavailable testosterone in men and …

Hand preference in humans is associated with testosterone levels and androgen receptor gene polymorphism

E Hampson, JS Sankar - Neuropsychologia, 2012 - Elsevier
… Strongly left-handed men were found to have lower testosterone than right-handed men.
► … testosterone levels in humans. In agreement with Witelson's hypothesis, however, …