… to fully reprogram bacteria as human therapeutics, including novel … bacterial engineering
for human therapies, but similar concepts can be applied for the development of live bacterial …

… use as an effective therapeutic agent. Engineered bacteria were the first organism modified
in the laboratory by manipulating the genetic sequence of bacteria to treat various diseases …

… testing of engineered bacterial diagnostics and therapeutics. We … engineered bacteria for
future clinical applications, and we discuss approaches to more efficiently evaluate engineered …

… One of the challenges of molecular therapy is how to deliver the therapeutic agent to the
offending bacterium. Phage delivery systems provide the opportunity to target specific bacterial …

… GEBs are not only effective therapeutic agents against chronic diseases due to their … The
use of engineered bacteria in disease treatment is still in the infancy stage and has limitations …

… could be either directly delivered to treat diseases, such as probiotics-mediated treatment
against ulcerative colitis, or utilized as carriers for therapeutic agents to increase the drug …

… In addition, we discuss novel strategies of cancer therapies integrating oncolytic bacteria, …
Engineered bacteria flood into tumor tissues and even small metastatic lesions follow blood …

… engineered bacteria applied to the field of antitumor therapy were outlined and the construction
methods of engineered bacteria … Nowadays, many kinds of therapeutic agents including …

… maximum tolerated dose – a single maximal dose of a therapeutic agent … bacterial-based
therapy. Future studies should first address whether tumors arising in genetically-engineered …

… of the use of engineered bacteria for the … engineered bacteria against cancer will not be
discussed here because it is the topic of a different article in this issue. Engineering bacteria …