The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … and targeted therapy, 2021 - nature.com
… levels of pro-inflammatory cytokines are produced during the crosstalk between epithelial
cells and immune cells in COVID-19, which has linked the cytokine storm (CS) with the severe …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
therapeutic approaches that aim to counterbalance the immune system and cytokine storm
… further investigations will help to understand which approaches are the most effective, if and …

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… elevation of the levels of multiple cytokines. In COVID‑19, this … Immunoregulatory therapies
target the cytokine storms induced … These approaches may be effective in the alleviation of …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… within the innate and adaptive immune systems, the understanding of this important
clinical syndrome is incomplete to date and effective therapeutic approaches remain scarce. …

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

D Panigrahy, MM Gilligan, S Huang, A Gartung… - Cancer and metastasis …, 2020 - Springer
… , may resolve the potentially fatal cytokine storm and severe pulmonary … cytokine suppression.
Thus, activating endogenous resolution pathways may be a novel therapeutic approach to …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - … Opinion on Therapeutic …, 2020 - Taylor & Francis
… been suggested that a cytokine storm of hyper-inflammation is … therapies which target the
COVID-19 induced cytokine storm. … Virus-induced cytokine storm is associated with Secondary …

[HTML][HTML] Agents to reduce cytokine storm

H Gerlach - F1000Research, 2016 - ncbi.nlm.nih.gov
cytokine stormcytokine storm with subsequent septic shock is the reason to take this field
of critical care medicine as an example to clarify pathophysiology and therapeutic approaches

[HTML][HTML] Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
… As cytokine storm is one of the most common causes of mortality in COVID-19, therapeutic
approaches to manage cytokine storm may provide a novel avenue to decrease the COVID-…

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
cytokine storm as a therapeutic approach to tackle COVID-19. In this review, we provide a
detailed insight into the cytokine storm … In addition, we discuss the potential therapeutic agents …

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
… Given the scenario, the systemic approach of simultaneous inhibition of NF-κB offers an …
with regard to cytokine storm in COVID-19. Moreover, the development of therapeutic strategies …