… release syndrome (CRS) [172], its targeting with anti-IL-6R monoclonal antibodies (eg, tocilizumab, sarilumab, siltuximab) is of main interest for therapeuticapproach. In this regard, …
N Panoskaltsis - Cancer Immunology, Immunotherapy, 2021 - Springer
… 2, the approach assumes that all cytokinestorms are the same … of the pathogenic cytokines in CRS, IL-6, with Tocilizumab … first- and second-line therapies for cytokinestorm induced by …
KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
… therapies and monoclonal antibodies cause cytokine release syndrome. Efforts are being carried out to maximize the chance for therapeutic … on the inflammatory cytokinestorm and its …
… Furthermore, cytokinestorm can cause post-COVID-19 … in COVID-19-related cytokinestorm and its association with multi-… potential therapeutic targets to control cytokinestorm wishing …
F Mannino, A Bitto, N Irrera - Frontiers in Pharmacology, 2020 - frontiersin.org
… to manage the several complications caused by an intense release of cytokines. This paper reviews the current options on drugs used to reduce the deadly effects of the cytokinestorm. …
… The immunomodulatory effect of the SCD in the excessive inflammatory state and cytokine storm differs from other current approaches to treat this dysregulated immunologic state. …
A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokinestorm… therapeuticapproach …
A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
… Disruption of the CCL-5-CCR5 axis therefore seems an attractive therapeuticapproach. An open-label study (phase 2) is currently ongoing to establish whether one week of treatment …
… of SARS-CoV-2, prevent disease progression and modulate the cytokinestorm in COVID-19. … approach to ratchet down the virulence of SARS-CoV-2 and modulate the cytokinestorm in …