Cytokine storm in COVID-19 and other diseases: emerging therapeutic interventions

S Sahu, R Dharra, M Gun, S Datta, AK Akela, A Kumar - Stem Cells, 2024 - Elsevier
… CAR T-cell therapy and associated cytokine storm. The CAR T-cell therapy approach is
used for treating different tumors such as lymphoma, ALL, CLL, and neuroblastoma. T cells are …

[HTML][HTML] Novel therapeutic approaches for treatment of COVID-19

N Hossein-Khannazer, B Shokoohian… - Journal of Molecular …, 2020 - Springer
… Here, we summarized the therapeutic approaches that are used … Lymphocytopenia, excessive
inflammation, and cytokine storm … , new therapeutic approaches including mesenchymal …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
… In examining leukocyte and cytokinecytokine responses lead to disease and/or organ
damage. By better understanding the mechanisms that drive the intensity of a cytokine storm, we …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… In spite of lacking specific anti-SARS-CoV-2 therapy, suppressing the cytokine storm with
corticosteroids is a common approach, which greatly improves the survival rate of COVID-19 …

Nanomedicine approaches to reduce cytokine storms in severe infections

MA Rauf, M Nisar, H Abdelhady, N Gavande… - Drug Discovery …, 2022 - Elsevier
therapies have potential to treat cytokine storm in infections. … We also detail the biology of
cytokine storms in severe infections, … outcomes with macrophage-based nanomedicine therapy. …

A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm

M Gong, S Qi, Z Wu, Y Huang, L Wu, X Wang, L He… - Cytokine, 2024 - Elsevier
… accepted definition for cytokine storm, coupled with ongoing … cytokine storm: elevated levels
of circulating cytokines, acute … mechanisms underlying the cytokine storm (severe sepsis). …

[HTML][HTML] Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
… the cytokine storm associated with inflammation and disease. This paper discusses the
cytokine storm syndrome … Such a synergistic therapeutic approach with the inclusion of natural …

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

M Aslani, SS Mortazavi-Jahromi, A Mirshafiey - International …, 2021 - Elsevier
… Identification and monitoring of these interventional elements can help us in designing the
miRNAs-based therapy for the reduction of complications/mortality rate in patients with severe/…

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

KB Walsh, JR Teijaro, PR Wilker… - Proceedings of the …, 2011 - National Acad Sciences
… -R inhibits cellular and cytokine/chemokine … cytokine storm playing a role in the pathogenesis
of a wide assortment of viral, bacterial, and immunologic diseases, a therapeutic approach

[HTML][HTML] Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
… array of multiple cytokines and chemokines, the potential therapeutic activity of tocilizumab
… personalized approach for a cytokine-targeted treatment of severe COVID-19 patients. …