The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?

J Floege - American journal of kidney diseases, 2011 - Elsevier
… represents yet another generic progression mechanism given that there is ample evidence
… run in defined phases, rather with many mechanisms operating in parallel, as illustrated by …

Immunity and immunopathology to viruses: what decides the outcome?

BT Rouse, S Sehrawat - Nature Reviews Immunology, 2010 - nature.com
… If anti-inflammatory mechanisms outweigh pro-inflammatory mechanisms, the pathogen could
persist in … and therapeutic approaches for viral infection and associated immunopathology. …

Cellular and molecular immunology approaches for the development of immunotherapies against the new coronavirus (SARS‐CoV‐2): challenges to near‐future …

JG Melgaco, D Brito e Cunha, T Azamor… - Journal of …, 2020 - Wiley Online Library
… the mechanism of host-virus interaction aimed at developing … In this review, both cellular
and molecular immunopathology … , has been pointed as a therapeutic approach. P-selectin is …

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
… the endothelium, an ideal therapeutic approach would be both antithrombotic and anti-inflammatory.
Here, we describe some of the main approaches that are being explored to address …

Immunological mechanisms in the pathogenesis of diabetic retinopathy

AP Adamis, AJ Berman - Seminars in immunopathology, 2008 - Springer
… There is an accumulating body of evidence that immunological mechanisms play a prominent
role … In addition, emerging therapeutic approaches based on ongoing investigations will be …

Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action

J Bayry, S Lacroix-Desmazes… - Nature Clinical Practice …, 2007 - nature.com
… are an effective therapeutic approach in certain rheumatic diseases. The mechanisms of
action … The success of currently available therapeutic immunoglobulins has led to considerable …

Clinical, immunopathologic, and therapeutic considerations of inflammatory myopathies

MC Dalakas - Clinical neuropharmacology, 1992 - journals.lww.com
… The evidence described above that immunopathologic mechanisms are primarily … therapies.
All of the treatment trials, however, have been empirical and large-scale control therapeutic

Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications

MG Roncarolo, S Gregori, R Bacchetta… - Interleukin-10 in Health …, 2014 - Springer
mechanisms of Tr1-cell–mediated suppression have been identified in vitro. It remains to
define how each of this mechanism … a de novo regulatory mechanism aimed to reduce the …

Mechanisms of cell death in Alzheimer disease—immunopathology

PL McGeer, EG McGeer - Alzheimer's Disease—From Basic Research to …, 1998 - Springer
… It is important to realize that this therapeutic approach to AD is very different from attempts
to replace the lost cholinergic activity or stimulate the cortical glucose metabolism. Such …

Update in the mechanisms of allergen-specific immunotheraphy

T Akkoc, M Akdis, CA Akdis - Allergy, asthma & immunology …, 2011 - synapse.koreamed.org
therapeutic approach for disregulated immune response towards allergens by enhancing
immune tolerance mechanisms. … is responsible for immunopathology and clinical scene. Once …