Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

P Mehta, JC Porter, JJ Manson, JD Isaacs… - The Lancet …, 2020 - thelancet.com
… rationale for therapeutic targeting of GM-CSF in COVID-19-associated hyperinflammation. …
and host defence, we discuss potential risks associated with inhibition of GM-CSF in the …

Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine

H Ibrahim, A Perl, D Smith, T Lewis, Z Kon… - Clinical …, 2020 - Elsevier
… The association between G6PD deficiency and COVID 19 has not yet been reported despite
… Interleukin-6 (IL-6) has been proposed to play an essential role in COVID-19 associated

Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study

E Della-Torre, C Campochiaro, G Cavalli… - Annals of the …, 2020 - ard.bmj.com
… Sarilumab was associated with faster recovery in a subset of … of COVID-19 response to
anti-inflammatory therapies.15 Indeed… conditions, was recently associated to clinical improvement …

Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study

G Cavalli, G De Luca, C Campochiaro… - The Lancet …, 2020 - thelancet.com
… available anti-inflammatory therapeutic options at the time of the COVID-19 outbreak. Low-…
might be needed to suppress COVID-19-related hyperinflammation. 29 patients received high-…

Cytokine storm in COVID-19: Potential therapeutics for immunomodulation

MM Rana - Journal of Research in Clinical Medicine, 2020 - library.2pressrelease.co.in
… in COVID-19 related hyperinflammation. It also emphasized on the efficacy of both synthetic
and natural therapeutic drugs for immunomodulation in the COVID-19 … that early blockade of …

[HTML][HTML] Hyper-inflammatory responses in COVID-19 and anti-inflammatory therapeutic approaches

H Choi, EC Shin - BMB reports, 2022 - ncbi.nlm.nih.gov
… injury and inflammation in patients with severe COVID-19 (29, 30… with COVID-19 exhibit
elevated gene expression related to … -6R), exerts therapeutic effects by blocking the binding of IL-…

… learned to date on COVID-19 hyperinflammatory syndrome: considerations for interventions to mitigate SARS-CoV-2 viral infection and detrimental hyperinflammation

M Cardone, M Yano, AS Rosenberg… - Frontiers in …, 2020 - frontiersin.org
… , termed COVID-19, is multifactorial and associated with both … these therapeutics according
to the stage of COVID-19 … an association of CD147 blockade by meplazumab, with an …

Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation

I Amigues, AH Pearlman, A Patel, P Reid… - Expert review of …, 2020 - Taylor & Francis
… severe COVID-19 infection as well as therapeutic strategies … with anakinra or other IL-1
blocking agents [Citation36] Serum … patients with COVID-19-associated hyperinflammation found …

Hyperinflammation and complement in COVID19

BG Pires, RT Calado - American Journal of Hematology, 2023 - Wiley Online Library
COVID-19 severity appears to be associated with the degree … with COVID-19 may benefit
from therapeutic complement … over-activated in COVID-19, blocking these pathways may …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
… a hyperinflammatory vasculopathy associated with COVID-19, … therapies for abrogating lung
injury in COVID-19. There are >… the IL-1R antagonist anakinra in blocking the activity of IL-1β …