[HTML][HTML] The drug repurposing for COVID-19 clinical trials provide very effective therapeutic combinations: lessons learned from major clinical studies

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
therapy, several combination therapies were also evaluated to understand the treatment of
COVID-19 from these significant clinical trials… on the therapeutic outcomes for COVID-19. The …

Combination therapies for COVID19: An overview of the clinical trials landscape

S Akinbolade, D Coughlan, R Fairbairn… - … journal of clinical …, 2022 - Wiley Online Library
… % of global COVID-19 clinical trials are testing combination therapies, with the majority
exploring dual combinations. As of 29 March 2021, there are 26 dual combination pivotal trials, of …

[HTML][HTML] Accelerating clinical evaluation of repurposed combination therapies for COVID-19

CR Rayner, L Dron, JJH Park, EH Decloedt… - The American Journal …, 2020 - ncbi.nlm.nih.gov
clinical evaluation strategy using adaptive combination platform trials to rapidly test combination
therapies to treat COVID-19clinical trials evaluating repurposed therapies for COVID-19. …

[HTML][HTML] Combating the pandemic COVID-19: clinical trials, therapies and perspectives

S Kotta, HM Aldawsari, SM Badr-Eldin… - Frontiers in molecular …, 2020 - frontiersin.org
… provides details on the clinical trials related to COVID-19, which are registered under
ClinicalTrials.gov. Potential of … are registered for the evaluation of this combination in COVID-19. …

[HTML][HTML] A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted

SW Wilz - Cytokine & Growth Factor Reviews, 2021 - Elsevier
… system are weak in patients with severe COVID-19 disease when compared to mild disease.
A … , a clinical trial that examines the use of the combination of IL-15 and IL-21 for COVID-19

Addressing COVID19 drug development with artificial intelligence

D Ho - Advanced Intelligent Systems, 2020 - Wiley Online Library
… to sustained efficacy in treating COVID-19. However, its emergence has also led to a large
number of clinical trials evaluating drug combinations composed of repurposed therapies. As …

Derivatization and combination therapy of current COVID-19 therapeutic agents: a review of mechanistic pathways, adverse effects, and binding sites

S El Kantar, B Nehmeh, P Saad, G Mitri, C Estephan… - Drug Discovery …, 2020 - Elsevier
clinical trials performed on drugs to treat COVID-19 patients. … We proposed combination
therapy using current COVID-19 … in the fight against COVID-19; clinical trials noted symptomatic …

Therapeutic options for COVID-19: a quick review

MS Ismaila, F Bande, A Ishaka, AA Sani… - Journal of …, 2020 - Taylor & Francis
… -emerging therapeutic compounds/drugs used in COVID-19 management and reports of
clinical trials, … involving 1061 individuals treated with AZT + HCQ combination before COVID-19

Current and future therapeutical approaches for COVID-19

Y Duan, Y Yao, SA Kumar, HL Zhu, J Chang - Drug Discovery Today, 2020 - Elsevier
… we focus on clinical trials involving drugs against COVID-19, potential clinical therapeutic
targets, and … By contrast, a recent clinical trial using these drug combinations failed to show any …

[HTML][HTML] Drug combination therapy for emerging viral diseases

ZA Shyr, YS Cheng, DC Lo, W Zheng - Drug discovery today, 2021 - Elsevier
… can be directly applied to clinical trials or potentially be used as emergency therapy. The
most … We foresee that more clinical results of drug combination therapy for COVID-19 will be …