Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
… This review summarizes the latest market trends and outlines the preeminent antibody
engineering technologies used in the development of therapeutic antibody drugs, such as …

The determination and interpretation of the therapeutic index in drug development

PY Muller, MN Milton - Nature reviews Drug discovery, 2012 - nature.com
… and interpretation in drug development for both small molecule drugs and biotherapeutics. …
during drug discovery and development for both small-molecule drugs and biotherapeutics. …

[HTML][HTML] Recent advances in (therapeutic protein) drug development

HAD Lagassé, A Alexaki, VL Simhadri… - …, 2017 - ncbi.nlm.nih.gov
… In this review, we highlight the emerging trends and approaches in protein drug
development by using examples of therapeutic proteins approved by the US Food and Drug

Advances in the development of new tuberculosis drugs and treatment regimens

A Zumla, P Nahid, ST Cole - Nature reviews Drug discovery, 2013 - nature.com
… weeks of therapy, 6 months of treatment with currently available drugs is required to … therapy
including the following: drug intolerance and toxicities, with the resultant need for treatment

Clinical development times for innovative drugs

DG Brown, HJ Wobst, A Kapoor, LA Kenna… - Nat Rev Drug …, 2022 - nature.com
… The two drugs with the shortest clinical development time … cancer treatment) and elexacaftor
(a cystic fibrosis treatment). … and the triple combination therapy including this drug, Trikafta, …

The prospects for “personalized medicine” in drug development and drug therapy

J Woodcock - Clinical Pharmacology & Therapeutics, 2007 - Wiley Online Library
… currently problematic states of both drug development and therapy. … drug therapies and the
promulgation of evidence-based best practices. Development of evidence-based therapeutic

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

S Tiberi, N du Plessis, G Walzl, MJ Vjecha… - The Lancet Infectious …, 2018 - thelancet.com
… as adjunctive therapy for shortening duration of therapy, preventing permanent lung injury,
and improving treatment outcomes of MDR tuberculosis. We discuss the HDT development

[PDF][PDF] Anti-angiogenic therapeutic drugs for treatment of human cancer

HC Wu, CT Huang, DK Chang - J Cancer Mol, 2008 - researchgate.net
… towards the development of drugs that disrupt or normalize this process for cancer therapy.
Some … In this review article, we summarize the clinical use of small molecules and therapeutic

New antituberculous drugs in development

UG Lalloo, A Ambaram - Current HIV/AIDS Reports, 2010 - Springer
… that are safe, effective against resistant strains, are able to shorten the course of treatment, …
with antiretroviral drugs. Drugs that are currently in phase 3 development are moxifloxacin …

Current and developing therapeutic agents in the treatment of Chagas disease

W Apt - Drug design, development and therapy, 2010 - Taylor & Francis
… It is important to point out that the drugs which are used in Chagas disease therapy must have
treatment of human Chagas disease in its different stages with the drugs currently in use. …