Role of pharmacokinetics and metabolism in drug discovery and development

JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …

Challenges in development of nanoparticle-based therapeutics

N Desai - The AAPS journal, 2012 - Springer
… medicines as a unique category of therapeutic agents, efforts are being made … development
and approval of nanoparticle-based therapeutics, and discusses potential strategies for drug

Drugs in development for influenza

DA Boltz, JR Aldridge, RG Webster, EA Govorkova - Drugs, 2010 - Springer
… , it is important that we develop novel anti-influenza drugs with broad reactivity against all
strains and subtypes, and consider moving to multiple drug therapy in the future. In this article …

Novel treatment strategies and drugs in development for cryptosporidiosis

MA Chavez, AC White Jr - Expert Review of Anti-Infective Therapy, 2018 - Taylor & Francis
… novel drugs and new compounds for the treatment of cryptosporidiosis. … development
of resistance suggests that we may eventually require drug combinations for optimal therapy

Therapeutic strategies for the treatment of stroke

AR Green, A Shuaib - Drug discovery today, 2006 - Elsevier
… Confidence in the correctness of this drug development approach to the treatment of acute …
so-called SAINT I trial) because the drug was found to significantly reduce disability (using the …

Classification of anticancer drugs—a new system based on therapeutic targets

E Espinosa, P Zamora, J Feliu, MG Barón - Cancer treatment reviews, 2003 - Elsevier
… These problems are delaying the development of antisense therapy. Another drug in this
group is angiozyme, which blocks the mRNA of the vascular endothelial growth factor [28], [29]. …

Therapeutic drug monitoring in the treatment of tuberculosis

CA Peloquin - Drugs, 2002 - Springer
… Given such high success rates, what could be the role of therapeutic drug monitoring (TDM)
in the treatment of TB? This paper explores those circumstances where the risk of treatment

Challenges in tuberculosis drug research and development

AM Ginsberg, M Spigelman - Nature medicine, 2007 - nature.com
… despite appropriate drug treatment are … therapy can be conceived as having four primary
goals: shortening and simplifying the treatment of active, drug-sensitive TB; improving therapy

Tumor necrosis factor antagonist therapy and lymphoma development: twenty‐six cases reported to the Food and Drug Administration

SL Brown, MH Greene, SK Gershon… - Arthritis & …, 2002 - Wiley Online Library
… The interval between initiation of therapy with etanercept or infliximab and the development
of … -TNF treatment, in the absence of specific cytotoxic therapy directed toward the lymphoma. …

Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine

D Ho, CHK Wang, EKH Chow - Science Advances, 2015 - science.org
… in drug design can have a profound impact on drug synergism and antagonism. A systematic
combination therapy developmentdrug dose ratios that result in globally optimal treatment