Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
… discuss how a deep insight into the physical and biological characteristics of biofilms can
inform therapeutic strategies and molecular targets for the development of anti-biofilm drugs. …

Tumor necrosis factor antagonist therapy and lymphoma development: twenty‐six cases reported to the Food and Drug Administration

SL Brown, MH Greene, SK Gershon… - Arthritis & …, 2002 - Wiley Online Library
… The interval between initiation of therapy with etanercept or infliximab and the development
of … -TNF treatment, in the absence of specific cytotoxic therapy directed toward the lymphoma. …

Combination of drugs and carriers in drug delivery technology and its development

Y Du, B Chen - Drug design, development and therapy, 2019 - Taylor & Francis
… The development of drug-loading technology will bring new and rapid development to the
treatment of diseases. At present, drug delivery by nanoparticles, erythrocyte, and platelet …

Nanodiamonds: the intersection of nanotechnology, drug development, and personalized medicine

D Ho, CHK Wang, EKH Chow - Science Advances, 2015 - science.org
… in drug design can have a profound impact on drug synergism and antagonism. A systematic
combination therapy developmentdrug dose ratios that result in globally optimal treatment

CNS Targets for multi-functional drugs in the treatment of Alzheimer's and Parkinson's diseases

MBH Youdim, JJ Buccafusco - Journal of neural transmission, 2005 - Springer
… It is likely that syndromes such as Alzheimer’s disease will require multiple drug therapy to
… of combining drugs with different therapeutic targets is workable, the development of multi…

Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug …

JK Coller, MR Hutchinson - Pharmacology & therapeutics, 2012 - Elsevier
In the past two decades a trickle of manuscripts examining the non-neuronal central nervous
system immune consequences of the drugs of abuse has now swollen to a significant body …

[HTML][HTML] Improving and accelerating drug development for nervous system disorders

DE Pankevich, BM Altevogt, J Dunlop, FH Gage… - Neuron, 2014 - cell.com
… comparison to other therapeutic areas. Current data suggest that drug development, from the
… This familiar statistic prompts an equally familiar question: can the therapeutic development

Targeting HIV: antiretroviral therapy and development of drug resistance

L Menendez-Arias - Trends in pharmacological sciences, 2002 - cell.com
… immunodeficiency virus type 1 (HIV-1), drug therapy has been used widely in the treatment
of AIDS. The loss of the therapeutic effect of zidovudine as a result of the acquisition of …

[HTML][HTML] Non-alcoholic steatohepatitis: limited available treatment options but promising drugs in development and recent progress towards a regulatory approval …

C Filozof, BJ Goldstein, RN Williams, A Sanyal - Drugs, 2015 - Springer
… for the treatment of NASH; however, no single therapy has been approved so far. Due to
the increasing prevalence and the health burden, there is a high need to develop therapeutic

[HTML][HTML] Drug repositioning: re-investigating existing drugs for new therapeutic indications

BM Padhy, YK Gupta - Journal of postgraduate medicine, 2011 - journals.lww.com
drug development strategy is exploration of drugs that have already been approved for
treatment of … [ 2 ] The process of finding new uses of existing drugs (marketed drugs and failed or …