Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
… and therapeutic efficacy in a hamster model of SARS-CoV-2 … be quickly elicited during natural
SARS-CoV-2 infection or by … ab1 has potential for therapy and prophylaxis of SARS-CoV-2 …

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

S Wang, Y Peng, R Wang, S Jiao, M Wang… - Nature …, 2020 - nature.com
… needs for COVID-19 therapy as no SARS-CoV-2-specific drugs … and therapeutic efficacy of
MW05/LALA on SARS-CoV-2 in … -based therapies for prophylactic and therapeutic treatment …

[HTML][HTML] Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

A Schäfer, DR Martinez, JJ Won, FR Moreira, AJ Brown… - BioRxiv, 2021 - ncbi.nlm.nih.gov
… Here, we demonstrate the in vitro antiviral activity and in vivo therapeutic efficacy of GS-…
antiviral activity in mice infected with SARS-CoV-2. Therapeutic GS-621763 significantly reduced …

Therapeutic efficacy of monoclonal antibodies and antivirals against SARS-CoV-2 Omicron BA. 1 in Syrian hamsters

R Uraki, M Kiso, M Imai, S Yamayoshi, M Ito… - Nature …, 2022 - nature.com
… of US Food and Drug Administration (FDA)-approved therapeutic mAbs against BA.1 …
SARS-CoV-2 research 7,8,9 . In addition, using this model, we evaluated the therapeutic efficacy of …

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Z Zhang, E Zeng, L Zhang, W Wang, Y Jin, J Sun… - Cell Discovery, 2021 - nature.com
… of antiviral therapies as we previously described 5 . Here we adopted this animal model for
evaluation of hACE2-Fc prophylactic and therapeutic efficacy against SARS-CoV-2 infection …

Repurposing therapeutics for potential treatment of SARS-CoV-2: a review

J Santos, S Brierley, MJ Gandhi, MA Cohen… - Viruses, 2020 - mdpi.com
… It also showed therapeutic efficacy against SARS-CoV in a … that therapies with evidence for
benefit in SARS-CoV and MERS-CoV infections are more likely to benefit patients with SARS-…

Update on therapeutic approaches and emerging therapies for SARS-CoV-2 virus

CA Omolo, N Soni, VO Fasiku, I Mackraj… - European Journal of …, 2020 - Elsevier
… be targeted by therapeutic agents for treatment of SARS-CoV-2 … treatment, while oxygen
therapy is employed for intervention in … drugs/therapeutic agents and treatment for SARS-CoV-2 …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
… recommended therapeutic agents, … therapeutic activity. The results of recent studies report
that hydroxychloroquine and convalescent plasma demonstrate no efficacy against SARS-CoV

Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection–a single-center, retrospective, cohort study

K Kautsch, J Wiśniowska… - European Journal of …, 2024 - Springer
… ) and Middle East respiratory syndrome coronavirus (MERS-CoV) was … therapeutic efficacy,
but its safety profile allowed the initiation of drug repurposing research, including SARS-CoV-…

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

R Yamin, AT Jones, HH Hoffmann, A Schäfer, KS Kao… - Nature, 2021 - nature.com
… we assessed the in vivo therapeutic activity of another neutralizing anti-SARS-CoV-2 monoclonal
antibody … 8), demonstrate improved therapeutic efficacy compared with wild-type IgG1. …