Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

W Li, C Chen, A Drelich, DR Martinez… - Proceedings of the …, 2020 - National Acad Sciences
… We also used the recently developed hamster model of SARS-CoV-2 infection (29, 30)
that allowed evaluation of both prophylactic and therapeutic efficacy of IgG1 ab1, although it …

[HTML][HTML] Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

TP Sheahan, AC Sims, SR Leist, A Schäfer… - Nature …, 2020 - nature.com
MERS-CoV patients most likely would initiate treatment after infection, we performed a series
of therapeutic efficacy … −/− hDPP4 mice infected with 5E + 04 pfu MERS-CoV on 1 dpi: RDV …

Novel Sars-CoV-2 Variants & Therapeutic Effects

RO Nyarko, R Roopini, V Raviteja, CG Awuchi… - Journal for Research in …, 2022 - jrasb.com
… :02 and B*27:07 alleles were connected to COVID-19 susceptibility in 99 Italians, whereas
HLAC*01 and B*44 alleles are strongly linked to SARSCoV-2 infection in Italy. The HLA-A*11:…

[HTML][HTML] Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Z Zhang, E Zeng, L Zhang, W Wang, Y Jin, J Sun… - Cell Discovery, 2021 - nature.com
… Unlike RBD-targeting neutralizing antibodies, hACE2-Fc treatment did not induce the … and
therapeutic hACE2-Fc treatments effectively protected mice from SARS-CoV-2 infection, as …

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

DK Ryu, R Song, M Kim, YI Kim, C Kim, JI Kim… - Biochemical and …, 2021 - Elsevier
… the wild type virus. … effect in B.1.351-infected animals was confirmed with a clinical dosage
of CT-P59, suggesting that CT-P59 has therapeutic potential for COVID-19 patients infected

Potential therapeutic effects of Resveratrol against SARS-CoV-2.

LH Ramdani, K Bachari - Acta virologica, 2020 - search.ebscohost.com
… Development of effective therapy thus became an emergency. This report aims to highlight
Resveratrol as possible therapeutic candidate in SARS-CoV-2 infection. The antiviral efficacy

[HTML][HTML] Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

S Wang, Y Peng, R Wang, S Jiao, M Wang… - Nature …, 2020 - nature.com
infectious diseases. Our results showed the prophylactic and therapeutic efficacy of MW05/LALA
on SARS-CoV-2 … antibody-based therapies for prophylactic and therapeutic treatment of …

[HTML][HTML] Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

A Schäfer, DR Martinez, JJ Won, FR Moreira, AJ Brown… - BioRxiv, 2021 - ncbi.nlm.nih.gov
… 8 hr after infection) would extend to later times post infection, we designed a therapeutic efficacy
… we varied both time of oral therapy initiation and dose level in BALB/c mice infected with …

[HTML][HTML] Therapeutic efficacy of monoclonal antibodies and antivirals against SARS-CoV-2 Omicron BA. 1 in Syrian hamsters

R Uraki, M Kiso, M Imai, S Yamayoshi, M Ito… - Nature …, 2022 - nature.com
therapeutic efficacy of small-molecule antiviral agents for COVID-19 against these variants.
… Thus, S309 showed less therapeutic effect against infection with D614G (HP095) compared …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
COVID-19 that either show no or only limited therapeutic … demonstrate no efficacy against
SARS-CoV-2 infection. Lastly, … or insufficient data concerning their effectiveness, such as …