Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
cytokine release in response to viral infection, a condition known as cytokine release
syndrome (CRS) or cytokine storm… timed anti-inflammatory therapeutic strategies could improve …

[HTML][HTML] Cytokine Storm and its Implication in Coronavirus disease 2019 (COVID-19)

C Datta, A Bhattacharjee - Journal of …, 2020 - immunologyresearchjournal.com
therapeutic drugs or vaccines are available to treat COVID-19. In this review, we intended to
describe how cytokine storm is … response due to cytokine storm during COVID-19 infection …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine stormstherapeutic

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
… ill COVID-19 patients, cytokine storm and cytokine dysregulation lead to remarkable
pathological consequences. Indeed, the cytokine storm elicits immunological changes that can …

Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity

S Maity, A Santra, AV Hebbani, S Pulakuntla… - Gene, 2023 - Elsevier
cytokine production response becomes crucial in developing an effective therapeutic strategy…
This review focuses on the potential targeting of COVID-19 associated cytokine storm and …

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… If the inflammatory reaction is very pronounced, an ultimately uncontrolled release of
proinflammatory cytokines leads to cytokine storm with the known potentially lethal courses [168]. …

[HTML][HTML] Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position …

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… overview of the cytokine storm and its implications in COVID-… that could be targeted for
therapy. Leveraging expert opinion, … on cytokine storm from both a prognostic and therapeutic

Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Future Medicine
… blockade may constitute an innovative therapeutic approach for … ‘cytokine storm’. This review
focuses on the pathological role of IL-6 in a cytokine storm and the therapeutic effect of IL-6

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… One of the main features of ARDS is the cytokine storm - an uncontrolled systemic … -inflammatory
cytokines and chemokines by immune effector cells [5]. High blood levels of cytokines

[HTML][HTML] Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… A cytokine storm is an uncontrolled, excessive immune … elevation of the levels of multiple
cytokines. In COVID‑19, this … Immunoregulatory therapies target the cytokine storms induced …