The last 5 yr have witnessed significant changes in research direction and new discoveries
about the mechanisms of neurodegeneration. Earlier studies on neuronal death focused on …

Stable obstructive coronary artery disease (CAD) and acute coronary syndromes (ACS)
result from the complex interplay between genetic factors and environmental exposures over …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection crucially worsens clinical evolution of coronavirus disease 2019 (COVID…

… of IL-1 family intranuclear actions in disease and to assess the therapeutic implications of
these … This could lead to the identification of novel therapeutics to treat inflammatory diseases. …

… The major signalling receptor for interleukin 1 (IL-1) in mammals is the IL-1RI (80 kDa),
which must associate with an accessory protein (AcP) to elicit signal transductiona. In the brain, …

… The cytokines interleukin 1 (IL1) and tumour necrosis factor α (TNFα) are produced acutely
as part … 15 This paper will focus on blocking IL1 as a therapeutic strategy for human disease. …

… IL-1 family are fundamental to innate immunity. Of the 11 members of the IL-1 family, IL-1β
has emerged as a therapeutic … or other parenteral therapies to reduce IL-1 activity. Blocking IL-…

Enhanced production of proinflammatory cytokines has been described in inflammatory bowel
disease. The effect of interleukin(IL)-10, a cytokine with antiinflammatory activity, or anti-IL-…

… The conclusions of this review are (1) that IL-1 is a key mediator of host responses to
microbial invasion, (2) that IL-1 represents a true hormone produced during infection and …

Cancer immunotherapy is designed to stimulate the immune system to reject and destroy
tumors. Recently, interleukin-15 (IL-15), a member of the four α-helix bundle family of cytokines…