Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis

LK Weaver, EM Behrens - Current treatment options in rheumatology, 2017 - Springer
… trigger malignancy-associated syndrome of hyperinflammation (… cytokine storm syndromes,
we outline a therapeutic approach that can be generalized across all forms of cytokine storm, …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storms (CSs) are associated with various pathologies, as observed in infectious
diseases… and autoinflammatory diseases, or following therapeutic interventions. Despite the …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
… differ, requiring the use of distinct intervention strategies to treat different diseases [136]. …
focuses on cytokine storms caused by infectious diseases. Infectious diseases that currently …

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

YM Gao, G Xu, B Wang, BC Liu - Journal of internal medicine, 2021 - Wiley Online Library
… All of these findings suggest that monocytes/macrophages play a crucial role in the development
of CSS after CAR T-cell therapy and enable new therapeutic interventions in this filed. …

Cytokine storms in infectious diseases

JR Teijaro - Seminars in immunopathology, 2017 - Springer
diseases and highlights emerging data that may point the way toward novel therapeutic
interventions… as future therapeutic options to ameliorate cytokine storm pathology during …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Therapeutic interventions that activate the immune system such as chimeric Ag receptor T
cell therapy … pandemic to bring increased attention to cytokine storm syndromes (CSSs) (1). …

Cytokine storm syndrome: looking toward the precision medicine era

EM Behrens, GA Koretzky - Arthritis & rheumatology, 2017 - Wiley Online Library
… In addition to the timing of therapeutic intervention (ie, patients were typically not … Treatment
of cytokine storm syndromes Put in simplest terms, treatment of cytokine storm syndromes

Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
… system dysregulation associated with CRS and acute respiratory distress syndrome in severe
COVID-19 is imperative to identify novel drug targets and other therapeutic interventions. …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
… as cytokine release syndrome (CRS) or cytokine storm, is … timed anti-inflammatory therapeutic
strategies could improve … to have immunomodulatory activities by interfering with Toll-…

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… associated cytokine storm syndrome. Thus, the identification of existing approved therapies
with … New therapeutic interventions will likely require a long lead time for the development of …