[HTML][HTML] A “window of therapeutic opportunity” for anti-cytokine therapy in patients with coronavirus disease 2019

L De Stefano, F Bobbio-Pallavicini, A Manzo… - Frontiers in …, 2020 - frontiersin.org
… syndromes characterized by cytokine storms, such as the cytokine release syndrome (CRS), …
The known sensitivity of these syndromes to cytokine-directed therapies has fueled many …

Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… , do trigger life-threatening “cytokine storms” in the host which can … cytokine storms which
may prove useful in the clinic in the future and compare them to more traditional therapeutic

Storm at the time of corona: a glimpse at the current understanding and therapeutic opportunities of the SARS-CoV-2 cytokine storm

M Torabi-Rahvar, N Rezaei - Current Pharmaceutical Design, 2021 - ingentaconnect.com
… with a cytokine storm and immune dysregulation. Increased pro-inflammatory cytokines
and … inflammatory response, a combination therapy approach using antiviral drugs plus anti-…

Cytokine storm in COVID-19: Potential therapeutics for immunomodulation

MM Rana - Journal of Research in Clinical Medicine, 2020 - library.2pressrelease.co.in
… Another way to restrain the excessive level of cytokine signalling or cytokine storm is the
use of Janus kinase inhibitors (JAKi).Most JAK inhibitors are specifically effective at JAK1 and …

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… A cytokine storm is an uncontrolled, excessive immune … elevation of the levels of multiple
cytokines. In COVID‑19, this … Immunoregulatory therapies target the cytokine storms induced …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - … Opinion on Therapeutic …, 2020 - Taylor & Francis
… been suggested that a cytokine storm of hyper-inflammation is … therapies which target the
COVID-19 induced cytokine storm. … Virus-induced cytokine storm is associated with Secondary …

Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm

N Morgulchik, F Athanasopoulou, E Chu… - Interface …, 2021 - royalsocietypublishing.org
therapies are now of interest in order to regulate the cytokine storm, and this review will
summarize and discuss advances in targeted therapies against cytokine storms induced by …

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives

CM Batista, L Foti - International Immunopharmacology, 2021 - Elsevier
cytokine storm has been observed in patients with severe disease characterized by a
proinflammatory cytokine … Thus, some treatment strategies focus on anti-cytokine storm nAbs. This …

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
… identify the cytokine storm. In this review, we referred COVID-19 associated cytokine storm as
… patients who are severely ill along with a high concentration of pro-inflammatory cytokines. …

[HTML][HTML] Nanomedicine therapies modulating macrophage dysfunction: a potential strategy to attenuate cytokine storms in severe infections

J Liu, M Wan, CJ Lyon, TY Hu - Theranostics, 2020 - ncbi.nlm.nih.gov
… on the pathology of cytokine storms in severe infections, highlight the role of macrophage
dysfunction in this process, and discuss nanomedicine-based therapies that could be used to …