[HTML][HTML] Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

P Mehta, JC Porter, JJ Manson, JD Isaacs… - The Lancet …, 2020 - thelancet.com
cytokine loop leading to monocyte and macrophage activation. This axis has been targeted
in cytokine storm … Here, we consider the scientific rationale for therapeutic targeting of GM-…

[HTML][HTML] Challenges and opportunities from targeting inflammatory responses to SARS-CoV-2 infection: a narrative review

V Lariccia, S Magi, T Serfilippi, M Toujani… - Journal of clinical …, 2020 - mdpi.com
… of pro-inflammatory cytokines (the so-called “cytokine storm”) drives morbidity and mortality
in the most severe cases. In the overall efforts made to develop effective and safe therapies (…

Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID‐19 pneumonia patients

B Borku Uysal, H Ikitimur, S Yavuzer… - Journal of medical …, 2020 - Wiley Online Library
… To predict the onset of cytokine storm, we believe that the increase in acute phase reactants
and routine clinical evaluation of the patient are sufficient and allow using the time wisely …

[HTML][HTML] SARS–CoV-2 immuno-pathogenesis and potential for diverse vaccines and therapies: opportunities and challenges

AR McGill, R Khalil, R Dutta, R Green, M Howell… - Infectious Disease …, 2021 - mdpi.com
… at risk for cytokine storm syndrome (CSS), organ damage, and thrombosis in response to
SARS-CoV-2 infection. The complexity of this viral infection warrants early interventions using …

Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling

BK Gajjela, MM Zhou - Drug discovery today, 2022 - Elsevier
… This lung hyper-inflammation is induced by virus-caused massive tissue damage that is
associated with uncontrolled cytokine release, known as a cytokine storm, through JAK/STAT …

Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges

G Liu, C Jiang, X Lin, Y Yang - View, 2021 - Wiley Online Library
… significance of cytokines. [ 3 ] The early recognition of cytokine storm by monitoring cytokine
levels … product for reducing the amount of cytokines in the bloodstream that control immune …

[HTML][HTML] Novel coronavirus disease 2019 (COVID-19) and cytokine storms for more effective treatments from an inflammatory pathophysiology

S Yokota, T Miyamae, Y Kuroiwa… - Journal of Clinical …, 2021 - mdpi.com
… In this paper, we will discuss the pathogenesis of cytokine storms associated with COVID-19,
clarify how to evaluate the pathophysiology that changes from time to time at bedside, and …

[HTML][HTML] The role of MSC therapy in attenuating the damaging effects of the cytokine storm induced by COVID-19 on the heart and cardiovascular system

GM Ellison-Hughes, L Colley, KA O'Brien… - Frontiers in …, 2020 - frontiersin.org
cytokine storm. In this review, we will discuss the mechanistic underpinnings of the cytokine
storm … potentially attenuate the damage caused by the cytokine storm induced by COVID-19. …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
… Current knowledge of cytokine and chemokine secretions resulting from host immunological
responses to SARS-CoV-2 infection, cytokine storm (CS), and related therapeutic

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… If the inflammatory reaction is very pronounced, an ultimately uncontrolled release of
proinflammatory cytokines leads to cytokine storm with the known potentially lethal courses [168]. …