The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine stormstherapeutic

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
… SARS-CoV-2 mediated cytokine storm is associated with the mortality and morbidity of
COVID-19 patients. The key cytokines implicated in the onset of disease severity include TNF-α, …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
… that release cytokines (notably IL-1, IL-6 and TNF) and … (cytokine storm) and tissue damage.
Some drugs have been studied as therapeutic targets (block to viral entry or to cytokine storm

Immunoregulatory therapy strategies that target cytokine storms in patients with COVID‑19

X Wang, Z He, X Zhao - Experimental and Therapeutic …, 2021 - spandidos-publications.com
… Immunoregulatory therapies target the cytokine storms induced by severe acute respiratory
syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes COVID‑19, and include …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… prominent cytokinecytokine levels while discussing cytokine sources and biological
functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm. …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … and targeted therapy, 2021 - nature.com
cytokines are produced during the crosstalk between epithelial cells and immune cells in
COVID-19, which has linked the cytokine storm … In addition, the challenges and prospects in the …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… have tried to implement therapies to mitigate the cytokine storm in the treatment of COVID…
cytokine storms, analyzing its role in COVID-19 and providing a critical analysis of the therapies

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - … Opinion on Therapeutic …, 2020 - Taylor & Francis
… Over-activity of chemotaxis triggers a macrophage activation syndrome (MAS) resulting
in the release of pro-inflammatory cytokines. IL-6 and TNF- α are at the forefront of hyper-…

Cytokine storm in COVID-19: An overview, mechanism, treatment strategies, and stem cell therapy perspective

NU Azmi, MU Puteri, D Lukmanto - … Sciences and Research, 2020 - scholarhub.ui.ac.id
… excessive amount of cytokine serum level (cytokine storm) has … Thus, the management of
the cytokine storm could be the … prospective treatment strategies for cytokine storm in COVID-19…

[PDF][PDF] Determining the disease outcome by cytokine storm during infectious diseases and targeting cytokines during sepsis: possible therapeutic options.

T Amin, A Hossain, FB Zahed - … and Experimental Therapeutics, 2022 - researchgate.net
… the major threat this cytokine storm-induced … the therapeutic interventions currently available
to treat sepsis to get an overview. We would also focus on the association of cytokine storm