ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

R Karki, SJ Lee, R Mall, N Pandian, Y Wang… - Science …, 2022 - science.org
… in severe COVID-19 to ward off deleterious effects of type I IFNs including cytokine storm. …
Together, our results show that ZBP1 drives cell death, cytokine storm, and lethality in β-…

Taming the cytokine storm: Biomechanical analysis of selective restriction of conformational interdomainal junctions of CD4 coreceptor in a sepsis model

E Abbas, D Mofed, TZ Salem - Medical Hypotheses, 2022 - Elsevier
… release of inflammatory cytokines leading to a cytokine storm. During the early priming phase
of the septic response; T-helper 1 (Th-1) secrete a distinct proinflammatory cytokine profile …

Potential for jaktinib hydrochloride to treat cytokine storms in patients with COVID-19

X Meng, Y Ling, L Zhang, Q Zhang, P Dong, T Zhu… - Bioscience …, 2020 - jstage.jst.go.jp
… inhibit cytokine storms in patients with COVID-19 (10,11). The current article describes the
pathogenesis of and relevant treatments for cytokine storms … those storms in clinical practice. …

[PDF][PDF] Nano-theragnostic Approach to Mitigate Covid-19

AK Verma - J Nanomed Nanotech, 2020 - academia.edu
… airway epithelial cells to repair the dysfunctions with therapy, drug repurposing to counter
the imbalance caused by the cytokine storm. Because inflammation, according to the literature, …

[PDF][PDF] Biochemical and immunological aspects of COVID-19 infection and therapeutical intervention of oral low dose cytokine therapy: a systematic review

M Ratheesh, S Sheethal, SP Jose, S Rajan… - Immunopharmacol …, 2021 - academia.edu
… an excessive generation of proinflammatory cytokines known as cytokine storm and also,
the … and effectiveness of oral low dose cytokines against the virus as a therapeutic approach. …

[HTML][HTML] Stem cell therapy: A promising treatment for COVID-19

ZX Zheng - World Journal of Clinical Cases, 2021 - ncbi.nlm.nih.gov
… COVID-19 can lead to a cytokine storm and patients usually have early respiratory signs …
Many clinical trials have proved that MSC therapy could be a potential feasible therapy for …

Tackling the cytokine storm using advanced drug delivery in allergic airway disease

VK Patel, S Vishwas, R Kumar, G De Rubis… - Journal of Drug Delivery …, 2023 - Elsevier
cytokines that triggers an uncontrolled aberrant inflammatory response known as ‘cytokine
storm’. This phenomenon interferes with the signalling and production of cytokines over time …

[PDF][PDF] Liver injury associated with acute respiratory distress syndrome and the prospects of mesenchymal stromal cells therapy for liver failure

O Redko, A Dovgalyuk, A Dovbush, Z Nebesna… - Therapy, 2021 - researchgate.net
… Coronavirus disease 2019 (COVID-19)-associated ARDS affects liver through the development
of systemic inflammatory response syndrome and hypoxia as well as cytokine storm. …

Complementary Pharmacological Treatment and Therapeutic Prospects for COVID-19

JA De Soto, F DSSc, ST Hakim, D Fouast - 2020 - osf.io
… with the cytokine storm that leads from pneumonia to ARDs. CONCLUSIONS: Developing
therapeutics interfering with the viral lifecycle, modulating the cytokine storm and protecting …

Nanomedicine for the SARS-CoV-2: state-of-the-art and future prospects

SP Varahachalam, B Lahooti… - International journal …, 2021 - Taylor & Francis
… one or two cytokines might not be adequate to mitigate cytokine storms and their ensuing …
therapeutic approaches that target the essential immune cells that facilitate cytokine storm