Molecular mechanisms regulating NLRP3 inflammasome activation

EK Jo, JK Kim, DM Shin, C Sasakawa - Cellular & molecular …, 2016 - nature.com
… Our knowledge of the mechanisms regulating NLRP3 inflammasometherapeutic strategies
to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome. …

Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases

JK Seok, HC Kang, YY Cho, HS Lee, JY Lee - Archives of Pharmacal …, 2021 - Springer
therapeutic applications targeting the NLRP3 inflammasome to … This review extensively
discusses NLRP3 inflammasome-… the design of therapeutic strategies for NLRP3 inflammasome-…

Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome

H Li, Y Guan, B Liang, P Ding, X Hou, W Wei… - European journal of …, 2022 - Elsevier
… therefore blocking NLRP3 inflammasome activation may represent a therapeutic strategy for
… that selectively blocks activation of the NLRP3 inflammasome. In recent years, research on …

Strategies for targeting the NLRP3 inflammasome in the clinical and preclinical space

AG Schwaid, KB Spencer - Journal of Medicinal Chemistry, 2020 - ACS Publications
… the excitement in the field for NLRP3 as a therapeutic target. As compounds progress, …
strategies have not been published, particularly considering the similar mode of action on NLRP3

The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
… blockade to treat NAFLD/NASH, and optimization of the therapeutic strategy for NAFLD
remains a major challenge. Future research directions should focus on agents with good results …

The role of NLRP3 inflammasome in diabetic cardiomyopathy and its therapeutic implications

K Ding, C Song, H Hu, K Yin, H Huang… - … Medicine and Cellular …, 2022 - Wiley Online Library
… the effect of the NLRP3 inflammasome on the major cellular … the NLRP3 inflammasome in
DCM and discuss several promising therapeutic strategies targeting the NLRP3 inflammasome

Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications

Y Duan, N Kelley, Y He - Neural regeneration research, 2020 - journals.lww.com
… There are three approved therapies that target the inflammasome downstream effector IL-1β…
NLRP3 inflammasome activation might represent a better therapeutic strategy to treat NLRP3

NLRP3 inflammasome: a new promising therapeutic target to treat heart failure

MG Del Buono, F Crea, F Versaci… - Journal of …, 2021 - journals.lww.com
inflammasome and activation of caspase-1, 5 and has recently emerged as a new therapeutic
strategy … through NLRP3 inflammasome inhibition is hypothesized to be a promising new …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
… the NLRP3 inflammasome pathway and alleviate neuroinflammation. Finally, we will summarize
the novel treatment strategiestherapeutic strategies for the treatment of these diseases. …

Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis

S Shao, C Chen, G Shi, Y Zhou, Y Wei, N Fan… - … & Therapeutics, 2021 - Elsevier
NLRP3 inflammasomeNLRP3 inflammasome activation plays a key role in the progression
of MS or EAE. Therefore, targeting the NLRP3 inflammasome might be a therapeutic strategy