Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors

N Zhao, C Li, B Di, L Xu - Journal of autoimmunity, 2020 - Elsevier
… some inhibitors as promising therapeutic strategies for diverse diseases driven by NLRP3
therapeutic usages of some inhibitors in various diseases related to NLRP3 inflammasome. …

The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers

M Gouravani, N Khalili, S Razi… - Expert Review of …, 2020 - Taylor & Francis
… As a member of the inflammasome family, the NLRP3 inflammasome has recently been … of
NLRP3 inflammasome activation, its role in specific types of tumors and the novel therapeutic

Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

D Liu, X Zeng, X Li, C Cui, R Hou, Z Guo… - Biochemical …, 2020 - Elsevier
… The importance of NLRP3 inflammasome in immunity and human diseases has been well …
of NLRP3 inflammasome complex and of its activation was thought to be therapeutic strategy

The NLRP3 inflammasome in the pathogenesis and treatment of Alzheimer's disease

M Golzari-Sorkheh, CE Brown… - Journal of …, 2021 - content.iospress.com
… Current therapeutic strategies targeting the NLRP3 axis consist of biologicals such as
anakinra, an IL-1β antagonist, and canakinumab, a neutralizing monoclonal antibody [76]. …

[HTML][HTML] NLRP3 inflammasome pathways in atherosclerosis

M Baldrighi, Z Mallat, X Li - Atherosclerosis, 2017 - Elsevier
… basic mechanisms of inflammasome activation and their … NLRP3 inflammasome activation,
and discuss the current findings and therapeutic strategies that target NLRP3 inflammasome

[HTML][HTML] The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions

RH Pirzada, N Javaid, S Choi - Genes, 2020 - mdpi.com
… The NLRP3 belongs to the subfamily of NLRP which activates … This inflammasome is
involved in multiple … Therefore, therapeutic targeting to the NLRP3 inflammasome complex is a …

[HTML][HTML] The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury

S Ismael, HA Ahmed, T Adris, K Parveen… - Neural regeneration …, 2021 - journals.lww.com
NLRP3 inflammasome in the pathophysiology of TBI, and current advances and challenges
in potential NLRP3-targeted therapies… effort to elucidate therapeutic strategies for attenuating …

[HTML][HTML] The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

R Chen, C Yin, J Fang, B Liu - Journal of neuroinflammation, 2021 - Springer
… review also summarized the successful therapeutic approaches that target against NLRP3
… the successful therapeutic approaches that target against NLRP3 inflammasome for chronic …

Therapeutic targeting of NLRP3 inflammasomes by natural products and pharmaceuticals: a novel mechanistic approach for inflammatory diseases

S Jahan, D Kumar, S Chaturvedi… - Current medicinal …, 2017 - ingentaconnect.com
NLRP3 inflammasome activity in acute and chronic inflammatory diseases. By modulating
the conformation of the NLRP3 inflammasome, selective therapeuticstherapeutic strategies

[HTML][HTML] The role of NLRP3 inflammasome in Alzheimer's disease and potential therapeutic targets

T Liang, Y Zhang, S Wu, Q Chen, L Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
… and downstream signaling pathways of the NLRP3 inflammasome, as well as the latest
developments regarding its potential targets and therapeutic strategies for AD treatment. …