… Activation of the NLRP3 inflammasome results in IL-1β … the NLRP3 inflammasome as a
therapeutic strategy. A hypothetical mechanism for the action of the NLRP3 inflammasome in …

NLRP3 inflammasome activation and IL-1β secretion have recently emerged as a central
mechanism in the pathogenesis of disease. Genetically defined syndromes like cryopyrin-…

… of the NLRP3 inflammasome and be beneficial for NLRP3-… to exert its anti-NLRP3
inflammasome activity in vitro and in … an effective therapeutic strategy for a wide range of NLRP3 …

… NLRP3 inflammasome activity in acute and chronic inflammatory diseases. By modulating
the conformation of the NLRP3 inflammasome, selective therapeutics … therapeutic strategies …

… activation of NLRP3 inflammasome may reduce … therapeutic strategy for this disease. In the
current review, we summarize the generally accepted mechanisms of NLRP3 inflammasome …

… and NLRP3 inflammasome activation, and then developing related drugs may bring new
hope for treatment. At present, therapeutic strategies targeting NLRP3 inflammasome mainly …

… novel therapeutic targets and innovative agents must be developed. Notably, the NLRP3
inflammasome is … As an innate immune supramolecular assembly, the NLRP3 inflammasome is …

… These findings suggest that novel therapeutic interventions at the molecular level might …
inhibition of NLRP3 inflammasome activation. Therefore, therapeutic strategies of inflammasome …

… activation combined with an in-depth understanding of how they contribute to AD
pathology, it might provide more cues for development of therapeutic strategies in AD. …

… The evidence discussed below provides a clear basis for NLRP3 inflammasome
inhibition/modulation to be considered as a therapeutic strategy to delay progression of this disease. …